{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gradauskaite V"],"funding":["Swiss National Science Foundation","Novartis Stiftung für Medizinisch-Biologische Forschung","European Research Council","Albert Heim Foundation"],"pagination":["e0311422"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9973313"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(1)"],"pubmed_abstract":["Wild-type canine distemper virus (CDV) is an important pathogen of dogs as well as wildlife that can infect immune and epithelial cells through two known receptors: the signaling lymphocytic activation molecule (SLAM) and nectin-4, respectively. Conversely, the ferret and egg-adapted CDV-Onderstepoort strain (CDV-OP) is employed as an effective vaccine for dogs. CDV-OP also exhibits promising oncolytic properties, such as its abilities to infect and kill multiple cancer cells <i>in vitro</i>. Interestingly, several cancer cells do not express SLAM or nectin-4, suggesting the presence of a yet unknown entry factor for CDV-OP. By conducting a genome-wide CRISPR/Cas9 knockout (KO) screen in CDV-OP-susceptible canine mammary carcinoma P114 cells, which neither express SLAM nor nectin-4, we ide"],"journal":["mBio"],"pubmed_title":["LRP6 Is a Functional Receptor for Attenuated Canine Distemper Virus."],"pmcid":["PMC9973313"],"funding_grant_id":["137","AdG-883877","189337","883877","3100030E_189337"],"pubmed_authors":["Scherer M","Dettwiler M","Plattet P","Gradauskaite V","Shrestha N","Doench J","Wyss M","Rottenberg S","Inglebert M"],"additional_accession":[]},"is_claimable":false,"name":"LRP6 Is a Functional Receptor for Attenuated Canine Distemper Virus.","description":"Wild-type canine distemper virus (CDV) is an important pathogen of dogs as well as wildlife that can infect immune and epithelial cells through two known receptors: the signaling lymphocytic activation molecule (SLAM) and nectin-4, respectively. Conversely, the ferret and egg-adapted CDV-Onderstepoort strain (CDV-OP) is employed as an effective vaccine for dogs. CDV-OP also exhibits promising oncolytic properties, such as its abilities to infect and kill multiple cancer cells <i>in vitro</i>. Interestingly, several cancer cells do not express SLAM or nectin-4, suggesting the presence of a yet unknown entry factor for CDV-OP. By conducting a genome-wide CRISPR/Cas9 knockout (KO) screen in CDV-OP-susceptible canine mammary carcinoma P114 cells, which neither express SLAM nor nectin-4, we ide","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2026-06-14T06:25:54.272Z","creation":"2025-02-19T04:54:28.842Z"},"accession":"S-EPMC9973313","cross_references":{"pubmed":["36645301"],"doi":["10.1128/mbio.03114-22"]}}