{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Maestas DR"],"funding":["HHS | National Institutes of Health","NEI NIH HHS","NCATS NIH HHS","NIA NIH HHS","NIAID NIH HHS","U.S. Department of Defense","NCI NIH HHS","NIAMS NIH HHS","HHS | NIH | National Eye Institute"],"pagination":["e2211703120"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9974432"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["120(8)"],"pubmed_abstract":["The immune system is increasingly recognized as an important regulator of tissue repair. We developed a regenerative immunotherapy from the helminth <i>Schistosoma mansoni</i> soluble egg antigen (SEA) to stimulate production of interleukin (IL)-4 and other type 2-associated cytokines without negative infection-related sequelae. The regenerative SEA (rSEA) applied to a murine muscle injury induced accumulation of IL-4-expressing T helper cells, eosinophils, and regulatory T cells and decreased expression of IL-17A in gamma delta (γδ) T cells, resulting in improved repair and decreased fibrosis. Encapsulation and controlled release of rSEA in a hydrogel further enhanced type 2 immunity and larger volumes of tissue repair. The broad regenerative capacity of rSEA was validated in articular jo"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Helminth egg derivatives as proregenerative immunotherapies."],"pmcid":["PMC9974432"],"funding_grant_id":["DP1 AR076959","DP1AR076959","T32 CA153952","HHSN272201700014C","KL2 TR001429","W81XWH-19-1-0576","R01 EY029055","T32 AG058527","R01EY029055"],"pubmed_authors":["Elisseeff JH","Pearce EJ","Pena AN","Ganguly S","Zhang H","Zack DJ","Mejia C","Sommerfeld SD","Nguyen HH","Anderson AE","Zhao L","Kelly SH","Andorko JI","Housseau F","Choi Y","Wang X","Woo J","Eric M","Chung L","Chin AF","Mejias JC","Hooks JST","Maestas DR","Krishnan K","Mahatme R","Han J","Berlinicke CA","Moore E","Pardoll DM"],"additional_accession":[]},"is_claimable":false,"name":"Helminth egg derivatives as proregenerative immunotherapies.","description":"The immune system is increasingly recognized as an important regulator of tissue repair. We developed a regenerative immunotherapy from the helminth <i>Schistosoma mansoni</i> soluble egg antigen (SEA) to stimulate production of interleukin (IL)-4 and other type 2-associated cytokines without negative infection-related sequelae. The regenerative SEA (rSEA) applied to a murine muscle injury induced accumulation of IL-4-expressing T helper cells, eosinophils, and regulatory T cells and decreased expression of IL-17A in gamma delta (γδ) T cells, resulting in improved repair and decreased fibrosis. Encapsulation and controlled release of rSEA in a hydrogel further enhanced type 2 immunity and larger volumes of tissue repair. The broad regenerative capacity of rSEA was validated in articular jo","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2025-04-04T22:55:13.261Z","creation":"2025-04-04T22:55:13.261Z"},"accession":"S-EPMC9974432","cross_references":{"pubmed":["36780522"],"doi":["10.1073/pnas.2211703120"]}}