{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["de Groot DH"],"funding":["Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (SNF)","Dutch Research Council (NWO)","Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung"],"pagination":["e2211091120"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9974493"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["120(8)"],"pubmed_abstract":["Microbes in the wild face highly variable and unpredictable environments and are naturally selected for their average growth rate across environments. Apart from using sensory regulatory systems to adapt in a targeted manner to changing environments, microbes employ bet-hedging strategies where cells in an isogenic population switch stochastically between alternative phenotypes. Yet, bet-hedging suffers from a fundamental trade-off: Increasing the phenotype-switching rate increases the rate at which maladapted cells explore alternative phenotypes but also increases the rate at which cells switch out of a well-adapted state. Consequently, it is currently believed that bet-hedging strategies are effective only when the number of possible phenotypes is limited and when environments last for s"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Effective bet-hedging through growth rate dependent stability."],"pmcid":["PMC9974493"],"funding_grant_id":["310030_184937","1228.191.283"],"pubmed_authors":["Tjalma AJ","van Nimwegen E","de Groot DH","Bruggeman FJ"],"additional_accession":[]},"is_claimable":false,"name":"Effective bet-hedging through growth rate dependent stability.","description":"Microbes in the wild face highly variable and unpredictable environments and are naturally selected for their average growth rate across environments. Apart from using sensory regulatory systems to adapt in a targeted manner to changing environments, microbes employ bet-hedging strategies where cells in an isogenic population switch stochastically between alternative phenotypes. Yet, bet-hedging suffers from a fundamental trade-off: Increasing the phenotype-switching rate increases the rate at which maladapted cells explore alternative phenotypes but also increases the rate at which cells switch out of a well-adapted state. Consequently, it is currently believed that bet-hedging strategies are effective only when the number of possible phenotypes is limited and when environments last for s","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2025-04-26T10:22:10.848Z","creation":"2025-04-06T13:18:11.659Z"},"accession":"S-EPMC9974493","cross_references":{"pubmed":["36780518"],"doi":["10.1073/pnas.2211091120"]}}