{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Krissberg JR"],"funding":["NCATS NIH HHS","NIDDK NIH HHS","NIAID NIH HHS"],"pagination":["318-328.e1"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9974571"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["81(3)"],"pubmed_abstract":["<h4>Rationale & objective</h4>The effects of race, ethnicity, socioeconomic status (SES), and disease severity on acute care utilization in patients with glomerular disease are unknown.<h4>Study design</h4>Prospective cohort study.<h4>Setting & participants</h4>1,456 adults and 768 children with biopsy-proven glomerular disease enrolled in the Cure Glomerulonephropathy (CureGN) cohort.<h4>Exposure</h4>Race and ethnicity as a participant-reported social factor.<h4>Outcome</h4>Acute care utilization defined as hospitalizations or emergency department visits.<h4>Analytical approach</h4>Multivariable recurrent event proportional rate models were used to estimate associations between race and ethnicity and acute care utilization.<h4>Results</h4>Black or Hispanic participants had lower SES and more severe glomerular disease than White or Asian participants. Acute care utilization rates were 45.6, 29.5, 25.8, and 19.2 per 100 person-years in Black, Hispanic, White, and Asian adults, respectively, and 55.8, 42.5, 40.8, and 13.0, respectively, for children. Compared with the White race (reference group), Black race was significantly associated with acute care utilization in adults (rate ratio [RR], 1.76 [95% CI, 1.37-2.27]), although this finding was attenuated after multivariable adjustment (RR, 1.31 [95% CI, 1.03-1.68]). Black race was not significantly associated with acute care utilization in children; Asian race was significantly associated with lower acute care utilization in children (RR, 0.32 [95% CI 0.14-0.70]); no significant associations between Hispanic ethnicity and acute care utilization were identified.<h4>Limitations</h4>We used proxies for SES and lacked direct information on income, household unemployment, or disability.<h4>Conclusions</h4>Significant differences in acute care utilization rates were observed across racial and ethnic groups in persons with prevalent glomerular disease, although many of these difference were explained by differences in SES and disease severity. Measures to combat socioeconomic disadvantage in Black patients and to more effectively prevent and treat glomerular disease are needed to reduce disparities in acute care utilization, improve patient wellbeing, and reduce health care costs."],"journal":["American journal of kidney diseases : the official journal of the National Kidney Foundation"],"pubmed_title":["Racial and Ethnic Disparities in Acute Care Utilization Among Patients With Glomerular Disease."],"pmcid":["PMC9974571"],"funding_grant_id":["U01 DK100876","U24 DK100845","T32 DK007110","UM1 DK100867","UM1 DK100845","UM1 DK100846","UM1 DK100876","UM1 DK100866","U01 DK100867","KL2 TR001874","U01 DK100866","U01 DK100846","K23 AI159073"],"pubmed_authors":["Wenderfer SE","Rizk D","Babayev R","Ghossein C","Heymann J","Appelbaum P","Russo P","Feig D","Jain A","Krissberg JR","Vento S","Kiryluk K","Renfrow M","Almaani S","Canetta P","Jain K","Bowers C","Stokes MB","Hannah M","Achanti A","Nast C","Novak J","Lin F","Gibson K","Kallash M","Sambandam K","Silva C","Swiatecka-Urban A","Parikh S","Smith AR","Selewski DT","Nester C","Massey H","Brathwaite KE","Matar RB","Al-Uzri A","Ayoub I","Wong C","Marasa M","Aviles DH","Claes D","O'Shaughnessy MM","Weaver DJ","Neu A","Tuttle K","Saha MK","Schelling J","Klein J","Holzman L","O'Toole J","Dreher M","Gonzalez-Vicente A","Mucha K","Liapis H","Hunley T","Hines W","Lugani F","Braun M","Vasylyeva TL","Devarajan P","Derebail V","Jens G","Sanna-Cherchi S","Gomez-Mendez L","Carlassara L","Adler S","Mika W","Moszczuk B","Rovin B","Rao M","Kogon A","Royal V","Fuentes GC","Gillespie B","Guay-Woodford LM","Helmuth ME","Sperati CJ","Abromovitz B","Chen D","Dukkipati R","Belsha C","Iragorri S","Ahn W","Bagnasco S","Katsoufis C","Fervenza F","Ashoor I","Sharpe S","Parekh RS","Ahn SY","Jefferson JA","Sedor J","Nickolas T","Fogo A","Steinke J","Mariani L","Khalid M","Kidd J","Kaskel F","Mahan J","Valeri A","Denburg M","Rasouly HM","Muthusamy S","Ghiggeri GM","Hou J","Vena N","Laurin LP","Dharnidharka V","Cai Y","Reidy K","Gbadegesin R","Yin HJ","Drexler Y","Weisstuch J","Lemley K","Mortiz M","Rheault M","Cramer C","Gomez AC","Lafayette R","CureGN Consortium","Sanghani N","Chan B","Cattran D","Hogan J","Foroncewicz B","Bartosh S","Meyers K","Perkowska-Ptasinska A","Hogan S","Sethna CB","Seeherunvong W","Dai T","Hodgin J","Chishti A","Sreedharan R","Chang A","Mason S","Appel G","Barcia J","Fernandez H","Ambruzs J","Winkler C","Boll P","D'Agati VD","Nestor JG","Wu M","Avila-Casado C","Oliverio A","Gharavi A","Brown E","Wang CS","Alpers C","Mohan S","Ganesan S","Hicken M","Wadhwani S","Poulton C","Fornoni A","Sethi S","Radhakrishnan J","Jennette JC","Pradhan M","Hladunewich M","Falk R","Kretzler M","Markowitz G","Gaut J","Mathews N","Zhdanova O","Gipson D","Smoyer W","Twombley K","Barisoni L","Nadasdy T","Mottl A","Stone H","Mongera N","Dogra S","Lane JC","Budisavljevic M","Baracco R","Uy N","Heather R","Husain SA","Gipson P","Kopp J","Waldman M","Bomback A","Shirazian S","Glenn DA","Srivastava T","Pan C","Erkan E","Fatima H","Greenbaum LA","Palmer M","Self S","Robinson B"],"additional_accession":[]},"is_claimable":false,"name":"Racial and Ethnic Disparities in Acute Care Utilization Among Patients With Glomerular Disease.","description":"<h4>Rationale & objective</h4>The effects of race, ethnicity, socioeconomic status (SES), and disease severity on acute care utilization in patients with glomerular disease are unknown.<h4>Study design</h4>Prospective cohort study.<h4>Setting & participants</h4>1,456 adults and 768 children with biopsy-proven glomerular disease enrolled in the Cure Glomerulonephropathy (CureGN) cohort.<h4>Exposure</h4>Race and ethnicity as a participant-reported social factor.<h4>Outcome</h4>Acute care utilization defined as hospitalizations or emergency department visits.<h4>Analytical approach</h4>Multivariable recurrent event proportional rate models were used to estimate associations between race and ethnicity and acute care utilization.<h4>Results</h4>Black or Hispanic participants had lower SES and more severe glomerular disease than White or Asian participants. Acute care utilization rates were 45.6, 29.5, 25.8, and 19.2 per 100 person-years in Black, Hispanic, White, and Asian adults, respectively, and 55.8, 42.5, 40.8, and 13.0, respectively, for children. Compared with the White race (reference group), Black race was significantly associated with acute care utilization in adults (rate ratio [RR], 1.76 [95% CI, 1.37-2.27]), although this finding was attenuated after multivariable adjustment (RR, 1.31 [95% CI, 1.03-1.68]). Black race was not significantly associated with acute care utilization in children; Asian race was significantly associated with lower acute care utilization in children (RR, 0.32 [95% CI 0.14-0.70]); no significant associations between Hispanic ethnicity and acute care utilization were identified.<h4>Limitations</h4>We used proxies for SES and lacked direct information on income, household unemployment, or disability.<h4>Conclusions</h4>Significant differences in acute care utilization rates were observed across racial and ethnic groups in persons with prevalent glomerular disease, although many of these difference were explained by differences in SES and disease severity. Measures to combat socioeconomic disadvantage in Black patients and to more effectively prevent and treat glomerular disease are needed to reduce disparities in acute care utilization, improve patient wellbeing, and reduce health care costs.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Mar","modification":"2026-05-03T03:27:07.975Z","creation":"2025-04-03T23:50:35.629Z"},"accession":"S-EPMC9974571","cross_references":{"pubmed":["36191724"],"doi":["10.1053/j.ajkd.2022.08.010"]}}