{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14"],"submitter":["Stocco E"],"pubmed_abstract":["Severe tracheal injuries that cannot be managed by mobilization and end-to-end anastomosis represent an unmet clinical need and an urgent challenge to face in surgical practice; within this scenario, decellularized scaffolds (eventually bioengineered) are currently a tempting option among tissue engineered substitutes. The success of a decellularized trachea is expression of a balanced approach in cells removal while preserving the extracellular matrix (ECM) architecture/mechanical properties. Revising the literature, many Authors report about different methods for acellular tracheal ECMs development; however, only few of them verified the devices effectiveness by an orthotopic implant in animal models of disease. To support translational medicine in this field, here we provide a systemati"],"journal":["Journal of tissue engineering"],"pagination":["20417314231151826"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9974632"],"repository":["biostudies-literature"],"pubmed_title":["Preclinical and clinical orthotopic transplantation of decellularized/engineered tracheal scaffolds: A systematic literature review."],"pmcid":["PMC9974632"],"pubmed_authors":["De Caro R","Macchi V","Porzionato A","Mammana M","Contran M","Stocco E","Rea F","Parnigotto PP","Conconi MT","Barbon S","Zambello G"],"additional_accession":[]},"is_claimable":false,"name":"Preclinical and clinical orthotopic transplantation of decellularized/engineered tracheal scaffolds: A systematic literature review.","description":"Severe tracheal injuries that cannot be managed by mobilization and end-to-end anastomosis represent an unmet clinical need and an urgent challenge to face in surgical practice; within this scenario, decellularized scaffolds (eventually bioengineered) are currently a tempting option among tissue engineered substitutes. The success of a decellularized trachea is expression of a balanced approach in cells removal while preserving the extracellular matrix (ECM) architecture/mechanical properties. Revising the literature, many Authors report about different methods for acellular tracheal ECMs development; however, only few of them verified the devices effectiveness by an orthotopic implant in animal models of disease. To support translational medicine in this field, here we provide a systemati","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan-Dec","modification":"2026-03-17T15:46:09.324Z","creation":"2025-08-17T03:05:53.725Z"},"accession":"S-EPMC9974632","cross_references":{"pubmed":["36874984"],"doi":["10.1177/20417314231151826"]}}