biostudies-literatureManubolu VSNational Center for Advancing Translational SciencesNCATS NIH HHSNHLBI NIH HHSNational Heart, Lung, and Blood InstituteNational Institutes of HealthNIAMS NIH HHS532-540https://www.ebi.ac.uk/biostudies/studies/S-EPMC9974807biostudies-literatureUnknown33(3)<h4>Background and aims</h4>Previously, osteoporosis and coronary artery disease were considered unrelated. However, beyond age, these two conditions appear to share common etiologies that are not yet fully understood. We examined the relationship between thoracic spine bone mineral density (BMD) and severity of coronary artery calcium (CAC) score.<h4>Methods and results</h4>MESA is a prospective cohort study of 6814 men and women between the ages of 45 and 84 years, without clinical cardiovascular disease. This study included participants who underwent non-contrast chest CT scans to determine CAC score and thoracic spine BMD. The thoracic spine BMD was categorized into osteoporosis (defined as T score: ≤ -2.5), osteopenia (T-score between: -2.5 and -1) and normal BMD (T-score ≥ -1). ThereNutrition, metabolism, and cardiovascular diseases : NMCDAssociation between coronary artery calcium and thoracic spine bone mineral density: Multiethnic Study of Atherosclerosis (MESA).PMC9974807R42 AR070713UL1-TR-001079UL1-TR-000040UL1 TR001420N01-HC-95161N01 HC095166N01 HC095165N01-HC-95162N01-HC-95163N01 HC095168N01-HC-95164N01 HC095167N01 HC095169N01-HC-95160N01-HC-951592R42AR07071375N92020D00007N01 HC095160N01 HC095162N01 HC095161N01 HC095164N01 HC09516375N92020D0000175N92020D0000275N92020D00005R01 HL07173975N92020D0000675N92020D0000375N92020D00004UL1 TR000040UL1-TR-001420HHSN268201500003CUL1 TR001079N01 HC095159N01-HC-95169R01 HL146666N01-HC-95165N01-HC-95166N01-HC-95167N01-HC-95168HHSN268201500003ICarr JJDailing CMao SHavistin RKinninger AGao YDahal SBudoff MJRoy SKAhmad KManubolu VSfalseAssociation between coronary artery calcium and thoracic spine bone mineral density: Multiethnic Study of Atherosclerosis (MESA).<h4>Background and aims</h4>Previously, osteoporosis and coronary artery disease were considered unrelated. However, beyond age, these two conditions appear to share common etiologies that are not yet fully understood. We examined the relationship between thoracic spine bone mineral density (BMD) and severity of coronary artery calcium (CAC) score.<h4>Methods and results</h4>MESA is a prospective cohort study of 6814 men and women between the ages of 45 and 84 years, without clinical cardiovascular disease. This study included participants who underwent non-contrast chest CT scans to determine CAC score and thoracic spine BMD. The thoracic spine BMD was categorized into osteoporosis (defined as T score: ≤ -2.5), osteopenia (T-score between: -2.5 and -1) and normal BMD (T-score ≥ -1). There2023-01-01T00:00:00Z2023 Mar2026-06-04T05:53:39.903Z2025-04-06T11:04:02.724ZS-EPMC99748073664260110.1016/j.numecd.2022.12.006