{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Malek-Ahmadi M"],"funding":["NCATS NIH HHS","NIA NIH HHS","National Institutes of Health","NIH HHS","National Institute on Aging"],"pagination":["112087"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9974847"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["173"],"pubmed_abstract":["<h4>Introduction</h4>The mechanisms linking motor function to Alzheimer's disease (AD) progression have not been well studied, despite evidence of AD pathology within motor brain regions. Thus, there is a need for new motor measure that is sensitive and specific to AD.<h4>Methods</h4>In a sample of 121 older adults (54 cognitive unimpaired [CU], 35 amnestic Mild Cognitive Impairment [aMCI], and 32 probable mild AD), intrasubject standard deviation (ISD) across six trials of a novel upper-extremity motor task was predicted with volumetric regional gray matter and neuropsychological scores using classification and regression tree (CART) analyses.<h4>Results</h4>Both gray matter and neuropsychological CART models indicated that motor task ISD (our measure of motor learning) was related to cor"],"journal":["Experimental gerontology"],"pubmed_title":["Volumetric regional MRI and neuropsychological predictors of motor task variability in cognitively unimpaired, Mild Cognitive Impairment, and probable Alzheimer's disease older adults."],"pmcid":["PMC9974847"],"funding_grant_id":["S10 OD018482","R01AG055428","K01 AG073578","R01 AG055428","P30 AG072980","UL1 TR002538"],"pubmed_authors":["Koppelmans V","Chen K","Duff K","Malek-Ahmadi M","Su Y","King JB","Schaefer SY"],"additional_accession":[]},"is_claimable":false,"name":"Volumetric regional MRI and neuropsychological predictors of motor task variability in cognitively unimpaired, Mild Cognitive Impairment, and probable Alzheimer's disease older adults.","description":"<h4>Introduction</h4>The mechanisms linking motor function to Alzheimer's disease (AD) progression have not been well studied, despite evidence of AD pathology within motor brain regions. Thus, there is a need for new motor measure that is sensitive and specific to AD.<h4>Methods</h4>In a sample of 121 older adults (54 cognitive unimpaired [CU], 35 amnestic Mild Cognitive Impairment [aMCI], and 32 probable mild AD), intrasubject standard deviation (ISD) across six trials of a novel upper-extremity motor task was predicted with volumetric regional gray matter and neuropsychological scores using classification and regression tree (CART) analyses.<h4>Results</h4>Both gray matter and neuropsychological CART models indicated that motor task ISD (our measure of motor learning) was related to cor","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Mar","modification":"2025-04-03T23:50:27.307Z","creation":"2025-04-03T23:50:27.307Z"},"accession":"S-EPMC9974847","cross_references":{"pubmed":["36639062"],"doi":["10.1016/j.exger.2023.112087"]}}