biostudies-literatureMalek-Ahmadi MNCATS NIH HHSNIA NIH HHSNational Institutes of HealthNIH HHSNational Institute on Aging112087https://www.ebi.ac.uk/biostudies/studies/S-EPMC9974847biostudies-literatureUnknown173<h4>Introduction</h4>The mechanisms linking motor function to Alzheimer's disease (AD) progression have not been well studied, despite evidence of AD pathology within motor brain regions. Thus, there is a need for new motor measure that is sensitive and specific to AD.<h4>Methods</h4>In a sample of 121 older adults (54 cognitive unimpaired [CU], 35 amnestic Mild Cognitive Impairment [aMCI], and 32 probable mild AD), intrasubject standard deviation (ISD) across six trials of a novel upper-extremity motor task was predicted with volumetric regional gray matter and neuropsychological scores using classification and regression tree (CART) analyses.<h4>Results</h4>Both gray matter and neuropsychological CART models indicated that motor task ISD (our measure of motor learning) was related to corExperimental gerontologyVolumetric regional MRI and neuropsychological predictors of motor task variability in cognitively unimpaired, Mild Cognitive Impairment, and probable Alzheimer's disease older adults.PMC9974847S10 OD018482R01AG055428K01 AG073578R01 AG055428P30 AG072980UL1 TR002538Koppelmans VChen KDuff KMalek-Ahmadi MSu YKing JBSchaefer SYfalseVolumetric regional MRI and neuropsychological predictors of motor task variability in cognitively unimpaired, Mild Cognitive Impairment, and probable Alzheimer's disease older adults.<h4>Introduction</h4>The mechanisms linking motor function to Alzheimer's disease (AD) progression have not been well studied, despite evidence of AD pathology within motor brain regions. Thus, there is a need for new motor measure that is sensitive and specific to AD.<h4>Methods</h4>In a sample of 121 older adults (54 cognitive unimpaired [CU], 35 amnestic Mild Cognitive Impairment [aMCI], and 32 probable mild AD), intrasubject standard deviation (ISD) across six trials of a novel upper-extremity motor task was predicted with volumetric regional gray matter and neuropsychological scores using classification and regression tree (CART) analyses.<h4>Results</h4>Both gray matter and neuropsychological CART models indicated that motor task ISD (our measure of motor learning) was related to cor2023-01-01T00:00:00Z2023 Mar2025-04-03T23:50:27.307Z2025-04-03T23:50:27.307ZS-EPMC99748473663906210.1016/j.exger.2023.112087