biostudies-literatureNicoletti PNIA NIH HHSNIDDK NIH HHSNCRR NIH HHSNIMH NIH HHSNHGRI NIH HHSNational Institute for Health Research (NIHR)NCI NIH HHS454-466https://www.ebi.ac.uk/biostudies/studies/S-EPMC9974860biostudies-literatureUnknown164(3)<h4>Background & aims</h4>Drug-induced liver injury (DILI) due to amoxicillin-clavulanate (AC) has been associated with HLA-A∗02:01, HLA-DRB1∗15:01, and rs2476601, a missense variant in PTPN22. The aim of this study was to identify novel risk factors for AC-DILI and to construct a genetic risk score (GRS).<h4>Methods</h4>Transcriptome-wide association study and genome-wide association study analyses were performed on 444 AC-DILI cases and 10,397 population-based controls of European descent. Associations were confirmed in a validation cohort (n = 133 cases and 17,836 population-based controls). Discovery and validation AC-DILI cases were also compared with 1358 and 403 non-AC-DILI cases.<h4>Results</h4>Transcriptome-wide association study revealed a significant association of AC-DILI risk GastroenterologyIdentification of Reduced ERAP2 Expression and a Novel HLA Allele as Components of a Risk Score for Susceptibility to Liver Injury Due to Amoxicillin-Clavulanate.PMC9974860U01 HG004603U01 DK065201U01 HG007417U01 HG004424U01 AG006781U01 CA155309UL1 RR025747U01 DK065184UL1 RR025761RC2 MH089964U01 HG004608R01 MH084098U01 HG004438U01 DK065211U01 DK083023U01 DK065176U01 DK083020U01 DK083027U01 DK100928U01 DK082992U24 DK065176BRC-1215-20003U01 DK065238UL1 RR024986U01 DK065193Drug-Induced Liver Injury Network (DILIN)Nicoletti PFontana RJBjornsson ESChalasani NLucena MILi YJStephens CAithal GPAndrade RJInternational Drug-Induced Liver Injury Consortium (iDILIC)Prospective European Drug-Induced Liver Injury (Pro-Euro DILI) InvestigatorsGovaere OWatkins PBBarnhart HXOdin JAInnocenti FDaly AKEtheridge ASDellinger ASerrano JStolz AGrove JIfalseIdentification of Reduced ERAP2 Expression and a Novel HLA Allele as Components of a Risk Score for Susceptibility to Liver Injury Due to Amoxicillin-Clavulanate.<h4>Background & aims</h4>Drug-induced liver injury (DILI) due to amoxicillin-clavulanate (AC) has been associated with HLA-A∗02:01, HLA-DRB1∗15:01, and rs2476601, a missense variant in PTPN22. The aim of this study was to identify novel risk factors for AC-DILI and to construct a genetic risk score (GRS).<h4>Methods</h4>Transcriptome-wide association study and genome-wide association study analyses were performed on 444 AC-DILI cases and 10,397 population-based controls of European descent. Associations were confirmed in a validation cohort (n = 133 cases and 17,836 population-based controls). Discovery and validation AC-DILI cases were also compared with 1358 and 403 non-AC-DILI cases.<h4>Results</h4>Transcriptome-wide association study revealed a significant association of AC-DILI risk 2023-01-01T00:00:00Z2023 Mar2026-06-01T17:22:24.161Z2025-04-04T20:40:38.055ZS-EPMC99748603649605510.1053/j.gastro.2022.11.036