biostudies-literatureUnknown13(1)Miyoshi YA miniaturized endoscopic laser system with laser steering has great potential to expand the application of minimally invasive laser treatment for micro-lesions inside narrow organs. The conventional systems require separate optical paths for endoscopic imaging and laser steering, which limits their application inside narrower organs. Herein, we present a novel endoscopic image-guided laser treatment system with a thin tip that can access inside narrow organs. The system uses a single fiber bundle to simultaneously acquire endoscopic images and modulate the laser-irradiated area. The insertion and operation of the system in a narrow space were demonstrated using an artificial vascular model. Repeated laser steering along set targets demonstrated accurate laser irradiation within a root-meaScientific reports2921https://www.ebi.ac.uk/biostudies/studies/S-EPMC9975189biostudies-literatureEndoscopic image-guided laser treatment system based on fiber bundle laser steering.PMC9975189Okayama KShimojo YAwazu KMiyoshi YNishimura TfalseEndoscopic image-guided laser treatment system based on fiber bundle laser steering.A miniaturized endoscopic laser system with laser steering has great potential to expand the application of minimally invasive laser treatment for micro-lesions inside narrow organs. The conventional systems require separate optical paths for endoscopic imaging and laser steering, which limits their application inside narrower organs. Herein, we present a novel endoscopic image-guided laser treatment system with a thin tip that can access inside narrow organs. The system uses a single fiber bundle to simultaneously acquire endoscopic images and modulate the laser-irradiated area. The insertion and operation of the system in a narrow space were demonstrated using an artificial vascular model. Repeated laser steering along set targets demonstrated accurate laser irradiation within a root-mea2023-01-01T00:00:00Z2023 Feb2025-04-22T10:04:14.9Z2025-04-05T23:23:03.629ZS-EPMC99751893685475610.1038/s41598-023-29392-4