{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ty M"],"funding":["NIAID NIH HHS"],"pagination":["eadd9012"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9976268"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(680)"],"pubmed_abstract":["Natural killer (NK) cells likely play an important role in immunity to malaria, but the effect of repeated malaria on NK cell responses remains unclear. Here, we comprehensively profiled the NK cell response in a cohort of 264 Ugandan children. Repeated malaria exposure was associated with expansion of an atypical, CD56<sup>neg</sup> population of NK cells that differed transcriptionally, epigenetically, and phenotypically from CD56<sup>dim</sup> NK cells, including decreased expression of PLZF and the Fc receptor γ-chain, increased histone methylation, and increased protein expression of LAG-3, KIR, and LILRB1. CD56<sup>neg</sup> NK cells were highly functional and displayed greater antibody-dependent cellular cytotoxicity than CD56<sup>dim</sup> NK cells. Higher frequencies of CD56<sup>n"],"journal":["Science translational medicine"],"pubmed_title":["Malaria-driven expansion of adaptive-like functional CD56-negative NK cells correlates with clinical immunity to malaria."],"pmcid":["PMC9976268"],"funding_grant_id":["K24 AI113002","U01 AI150741","U19 AI089674","R01 AI093615"],"pubmed_authors":["Callaway PC","Tukwasibwe S","Hu Z","Andrew D","Khatri P","Greenhouse B","Rek J","Blish C","Arinaitwe E","Takahashi S","Klemm S","Greenleaf W","Musinguzi K","Sun S","Nankya F","Feeney M","Kamya M","Ssewanyana I","Donato M","Jagannathan P","Lewis SN","Rodriguez-Barraquer I","Nideffer J","de la Parte L","Mori DM","Press KD","van der Ploeg K","Boyle M","Ty M","Dorsey G","Utz PJ"],"additional_accession":[]},"is_claimable":false,"name":"Malaria-driven expansion of adaptive-like functional CD56-negative NK cells correlates with clinical immunity to malaria.","description":"Natural killer (NK) cells likely play an important role in immunity to malaria, but the effect of repeated malaria on NK cell responses remains unclear. Here, we comprehensively profiled the NK cell response in a cohort of 264 Ugandan children. Repeated malaria exposure was associated with expansion of an atypical, CD56<sup>neg</sup> population of NK cells that differed transcriptionally, epigenetically, and phenotypically from CD56<sup>dim</sup> NK cells, including decreased expression of PLZF and the Fc receptor γ-chain, increased histone methylation, and increased protein expression of LAG-3, KIR, and LILRB1. CD56<sup>neg</sup> NK cells were highly functional and displayed greater antibody-dependent cellular cytotoxicity than CD56<sup>dim</sup> NK cells. Higher frequencies of CD56<sup>n","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2025-04-04T20:04:10.477Z","creation":"2025-04-04T20:04:10.477Z"},"accession":"S-EPMC9976268","cross_references":{"pubmed":["36696483"],"doi":["10.1126/scitranslmed.add9012"]}}