biostudies-literatureTian SNational Natural Scientific Foundation of China8https://www.ebi.ac.uk/biostudies/studies/S-EPMC9976393biostudies-literatureUnknown160(1)<h4>Background</h4>Neuropathic pain (NP) is one of the most common types of chronic pain and significantly compromises the quality of life. Autophagy is an intracellular catabolic process that is required to maintain cellular homeostasis in response to various stresses. The role of autophagy-related genes in the diagnosis and treatment of neuropathic pain remains unclear.<h4>Methods</h4>We identified autophagy-related differentially expressed genes (ARDEGs) and differentially expressed miRNAs (DE-miRNAs) in neuropathic pain by bioinformatics analysis of the GSE145226 and GSE145199 datasets. These ARDEGs and their co-expressed genes were subjected to Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis, Gene Set Enrichment Analysis (GSEA) and friends analysHereditasIdentification of autophagy-related genes in neuropathic pain through bioinformatic analysis.PMC99763938216022731860293Wu LZheng HTian SZhong XWu WYu XfalseIdentification of autophagy-related genes in neuropathic pain through bioinformatic analysis.<h4>Background</h4>Neuropathic pain (NP) is one of the most common types of chronic pain and significantly compromises the quality of life. Autophagy is an intracellular catabolic process that is required to maintain cellular homeostasis in response to various stresses. The role of autophagy-related genes in the diagnosis and treatment of neuropathic pain remains unclear.<h4>Methods</h4>We identified autophagy-related differentially expressed genes (ARDEGs) and differentially expressed miRNAs (DE-miRNAs) in neuropathic pain by bioinformatics analysis of the GSE145226 and GSE145199 datasets. These ARDEGs and their co-expressed genes were subjected to Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis, Gene Set Enrichment Analysis (GSEA) and friends analys2023-01-01T00:00:00Z2023 Mar2026-04-08T14:11:55.352Z2025-04-07T05:08:27.315ZS-EPMC99763933685521710.1186/s41065-023-00269-w