{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["van de Stadt LA"],"funding":["Dutch Arthritis Society"],"pagination":["1350-1355"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9977113"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["62(3)"],"pubmed_abstract":["<h4>Objectives</h4>To investigate whether biomarkers are modulated by prednisolone treatment in patients with hand OA and whether they can predict response to prednisolone.<h4>Methods</h4>Biomarkers reflecting tissue turnover and inflammation [aggrecanase-derived neoepitope of arggecan (ARGS), MMP-derived neoepitope of type I collagen (C1M), MMP-derived neoepitope of type III collagen (C3M), marker of true type V collagen formation (PROC5), MMP-derived neoepitope of CRP (CRPM), citrullinated vimentin fragment (VICM), high-sensitivity (hsCRP)] were measured in sera from 78 patients with painful inflammatory hand OA, who were randomized between prednisolone or placebo treatment. Association of baseline biomarker levels with disease characteristics [visual analogue scale (VAS) pain, synovial "],"journal":["Rheumatology (Oxford, England)"],"pubmed_title":["Serum biomarkers in prednisolone-treated hand osteoarthritis patients."],"pmcid":["PMC9977113"],"funding_grant_id":["14-1-303"],"pubmed_authors":["Kroon FPB","Bay-Jensen AC","Kloppenburg M","van de Stadt LA","Thudium CF"],"additional_accession":[]},"is_claimable":false,"name":"Serum biomarkers in prednisolone-treated hand osteoarthritis patients.","description":"<h4>Objectives</h4>To investigate whether biomarkers are modulated by prednisolone treatment in patients with hand OA and whether they can predict response to prednisolone.<h4>Methods</h4>Biomarkers reflecting tissue turnover and inflammation [aggrecanase-derived neoepitope of arggecan (ARGS), MMP-derived neoepitope of type I collagen (C1M), MMP-derived neoepitope of type III collagen (C3M), marker of true type V collagen formation (PROC5), MMP-derived neoepitope of CRP (CRPM), citrullinated vimentin fragment (VICM), high-sensitivity (hsCRP)] were measured in sera from 78 patients with painful inflammatory hand OA, who were randomized between prednisolone or placebo treatment. Association of baseline biomarker levels with disease characteristics [visual analogue scale (VAS) pain, synovial ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Mar","modification":"2025-04-04T08:35:46.007Z","creation":"2025-04-04T08:35:46.007Z"},"accession":"S-EPMC9977113","cross_references":{"pubmed":["35946535"],"doi":["10.1093/rheumatology/keac442"]}}