biostudies-literaturevan de Stadt LADutch Arthritis Society1350-1355https://www.ebi.ac.uk/biostudies/studies/S-EPMC9977113biostudies-literatureUnknown62(3)<h4>Objectives</h4>To investigate whether biomarkers are modulated by prednisolone treatment in patients with hand OA and whether they can predict response to prednisolone.<h4>Methods</h4>Biomarkers reflecting tissue turnover and inflammation [aggrecanase-derived neoepitope of arggecan (ARGS), MMP-derived neoepitope of type I collagen (C1M), MMP-derived neoepitope of type III collagen (C3M), marker of true type V collagen formation (PROC5), MMP-derived neoepitope of CRP (CRPM), citrullinated vimentin fragment (VICM), high-sensitivity (hsCRP)] were measured in sera from 78 patients with painful inflammatory hand OA, who were randomized between prednisolone or placebo treatment. Association of baseline biomarker levels with disease characteristics [visual analogue scale (VAS) pain, synovial Rheumatology (Oxford, England)Serum biomarkers in prednisolone-treated hand osteoarthritis patients.PMC997711314-1-303Kroon FPBBay-Jensen ACKloppenburg Mvan de Stadt LAThudium CFfalseSerum biomarkers in prednisolone-treated hand osteoarthritis patients.<h4>Objectives</h4>To investigate whether biomarkers are modulated by prednisolone treatment in patients with hand OA and whether they can predict response to prednisolone.<h4>Methods</h4>Biomarkers reflecting tissue turnover and inflammation [aggrecanase-derived neoepitope of arggecan (ARGS), MMP-derived neoepitope of type I collagen (C1M), MMP-derived neoepitope of type III collagen (C3M), marker of true type V collagen formation (PROC5), MMP-derived neoepitope of CRP (CRPM), citrullinated vimentin fragment (VICM), high-sensitivity (hsCRP)] were measured in sera from 78 patients with painful inflammatory hand OA, who were randomized between prednisolone or placebo treatment. Association of baseline biomarker levels with disease characteristics [visual analogue scale (VAS) pain, synovial 2023-01-01T00:00:00Z2023 Mar2025-04-04T08:35:46.007Z2025-04-04T08:35:46.007ZS-EPMC99771133594653510.1093/rheumatology/keac442