biostudies-literatureSzilagyi IANetherlands Organisation for Health Research and Development1286-1295https://www.ebi.ac.uk/biostudies/studies/S-EPMC9977119biostudies-literatureUnknown62(3)<h4>Objectives</h4>The aim of this study was to identify biomarkers for radiographic OA severity and progression acting within the inflammation and metabolic pathways.<h4>Methods</h4>For 3517 Rotterdam Study participants, 184 plasma protein levels were measured using Olink inflammation and cardiometabolic panels. We studied associations with severity and progression of knee, hip and hand OA and a composite overall OA burden score by multivariable regression models, adjusting for age, sex, cell counts and BMI.<h4>Results</h4>We found 18 significantly associated proteins for overall OA burden, of which 5 stayed significant after multiple testing correction: circulating cartilage acidic protein 1 (CRTAC1), cartilage oligomeric matrix protein (COMP), thrombospondin 4, IL-18 receptor 1 (IL-18R1Rheumatology (Oxford, England)Plasma proteomics identifies CRTAC1 as a biomarker for osteoarthritis severity and progression.PMC9977119849200003Boer CGBierma-Zeinstra SMASzilagyi IAIkram MAvan Meurs JBJVallerga CLSchiphof DfalsePlasma proteomics identifies CRTAC1 as a biomarker for osteoarthritis severity and progression.<h4>Objectives</h4>The aim of this study was to identify biomarkers for radiographic OA severity and progression acting within the inflammation and metabolic pathways.<h4>Methods</h4>For 3517 Rotterdam Study participants, 184 plasma protein levels were measured using Olink inflammation and cardiometabolic panels. We studied associations with severity and progression of knee, hip and hand OA and a composite overall OA burden score by multivariable regression models, adjusting for age, sex, cell counts and BMI.<h4>Results</h4>We found 18 significantly associated proteins for overall OA burden, of which 5 stayed significant after multiple testing correction: circulating cartilage acidic protein 1 (CRTAC1), cartilage oligomeric matrix protein (COMP), thrombospondin 4, IL-18 receptor 1 (IL-18R12023-01-01T00:00:00Z2023 Mar2025-04-05T14:20:00.386Z2025-04-05T14:20:00.386ZS-EPMC99771193592496210.1093/rheumatology/keac415