{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Donnelly EL"],"funding":["NICHD NIH HHS","NIAID NIH HHS"],"pagination":["630-641"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9977167"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6(8)"],"pubmed_abstract":["We have recently demonstrated that basophils are protective against intestinal permeability during malaria and contribute to reduced parasite transmission to mosquitoes. Given that IL-18 is an early cytokine/alarmin in malaria and has been shown to activate basophils, we sought to determine the role of the basophil IL-18R in this protective phenotype. To address this, we infected control [<i>IL18r</i> <sup>flox/flox</sup> or basoIL-18R (+)] mice and mice with basophils lacking the IL-18R [<i>IL18r</i> <sup>flox/flox</sup> × Basoph8 or basoIL-18R (-)] with <i>Plasmodium yoelii yoelii</i> 17XNL, a nonlethal strain of mouse malaria. Postinfection (PI), intestinal permeability, ileal mastocytosis, bacteremia, and levels of ileal and plasma cytokines and chemokines were measured through 10 d PI"],"journal":["ImmunoHorizons"],"pubmed_title":["The Basophil IL-18 Receptor Precisely Regulates the Host Immune Response and Malaria-Induced Intestinal Permeability and Alters Parasite Transmission to Mosquitoes without Effect on Gametocytemia."],"pmcid":["PMC9977167"],"funding_grant_id":["P50 HD103526","R01 AI165481","R01 AI131609"],"pubmed_authors":["Schauer J","Van de Water J","Donnelly EL","Wagers D","Hansten G","Luckhart S","Cespedes N","Briggs AM","Lowder C","Haapanen L"],"additional_accession":[]},"is_claimable":false,"name":"The Basophil IL-18 Receptor Precisely Regulates the Host Immune Response and Malaria-Induced Intestinal Permeability and Alters Parasite Transmission to Mosquitoes without Effect on Gametocytemia.","description":"We have recently demonstrated that basophils are protective against intestinal permeability during malaria and contribute to reduced parasite transmission to mosquitoes. Given that IL-18 is an early cytokine/alarmin in malaria and has been shown to activate basophils, we sought to determine the role of the basophil IL-18R in this protective phenotype. To address this, we infected control [<i>IL18r</i> <sup>flox/flox</sup> or basoIL-18R (+)] mice and mice with basophils lacking the IL-18R [<i>IL18r</i> <sup>flox/flox</sup> × Basoph8 or basoIL-18R (-)] with <i>Plasmodium yoelii yoelii</i> 17XNL, a nonlethal strain of mouse malaria. Postinfection (PI), intestinal permeability, ileal mastocytosis, bacteremia, and levels of ileal and plasma cytokines and chemokines were measured through 10 d PI","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Aug","modification":"2025-04-04T00:35:43.272Z","creation":"2025-04-04T00:35:43.272Z"},"accession":"S-EPMC9977167","cross_references":{"pubmed":["35985797"],"doi":["10.4049/immunohorizons.2200057"]}}