biostudies-literatureHsu CLNIA NIH HHSCanadian Institute for Health ResearchNational Institute on AgingCIHR521-526https://www.ebi.ac.uk/biostudies/studies/S-EPMC9977250biostudies-literatureUnknown78(3)<h4>Background</h4>Slow gait is predictive of functional impairments in older adults, while concomitant slow gait and cognitive complaints are associated with a greater risk for cognitive decline and dementia. However, functional neural correlates for gait speed maintenance are unclear. As the sensorimotor network (SMN) and frontoparietal network (FPN) are integral components of these functions, this study investigated differences in SMN and FPN in older adults with/without gait speed decline over 24 months; and whether these networks were associated with the maintenance of cognitive function.<h4>Methods</h4>We included 42 community-dwelling older adults aged >70 years from the MOBILIZE Boston Study. Resting-state fMRI was performed at the study baseline. Participant characteristics, gait The journals of gerontology. Series A, Biological sciences and medical sciencesSensorimotor and Frontoparietal Network Connectivity Are Associated With Subsequent Maintenance of Gait Speed and Episodic Memory in Older Adults.PMC9977250R01 AG041785R21 AG064575R01-AG059089R21-AG064575Lipsitz LAManor BHsu CLTravison TPascual-Leone AfalseSensorimotor and Frontoparietal Network Connectivity Are Associated With Subsequent Maintenance of Gait Speed and Episodic Memory in Older Adults.<h4>Background</h4>Slow gait is predictive of functional impairments in older adults, while concomitant slow gait and cognitive complaints are associated with a greater risk for cognitive decline and dementia. However, functional neural correlates for gait speed maintenance are unclear. As the sensorimotor network (SMN) and frontoparietal network (FPN) are integral components of these functions, this study investigated differences in SMN and FPN in older adults with/without gait speed decline over 24 months; and whether these networks were associated with the maintenance of cognitive function.<h4>Methods</h4>We included 42 community-dwelling older adults aged >70 years from the MOBILIZE Boston Study. Resting-state fMRI was performed at the study baseline. Participant characteristics, gait 2023-01-01T00:00:00Z2023 Mar2025-04-27T03:46:59.293Z2025-04-06T18:56:08.799ZS-EPMC99772503612471110.1093/gerona/glac193