biostudies-literatureGuttesen AAVMedical Research Council Career Development AwardMedical Research CouncilUniversity of York Department of Psychology Doctoral Studentship1610-1625https://www.ebi.ac.uk/biostudies/studies/S-EPMC9977378biostudies-literatureUnknown33(5)Sleep supports memory consolidation as well as next-day learning. The influential "Active Systems" account of offline consolidation suggests that sleep-associated memory processing paves the way for new learning, but empirical evidence in support of this idea is scarce. Using a within-subjects (n = 30), crossover design, we assessed behavioral and electrophysiological indices of episodic encoding after a night of sleep or total sleep deprivation in healthy adults (aged 18-25 years) and investigated whether behavioral performance was predicted by the overnight consolidation of episodic associations from the previous day. Sleep supported memory consolidation and next-day learning as compared to sleep deprivation. However, the magnitude of this sleep-associated consolidation benefit did not sCerebral cortex (New York, N.Y. : 1991)Sleep loss disrupts the neural signature of successful learning.PMC9977378MR/P020208/1Cross ZRGuttesen AAVCairney SAMadden EVGaskell MGAppleby GfalseSleep loss disrupts the neural signature of successful learning.Sleep supports memory consolidation as well as next-day learning. The influential "Active Systems" account of offline consolidation suggests that sleep-associated memory processing paves the way for new learning, but empirical evidence in support of this idea is scarce. Using a within-subjects (n = 30), crossover design, we assessed behavioral and electrophysiological indices of episodic encoding after a night of sleep or total sleep deprivation in healthy adults (aged 18-25 years) and investigated whether behavioral performance was predicted by the overnight consolidation of episodic associations from the previous day. Sleep supported memory consolidation and next-day learning as compared to sleep deprivation. However, the magnitude of this sleep-associated consolidation benefit did not s2023-01-01T00:00:00Z2023 Feb2026-03-17T16:00:07.367Z2025-04-04T08:35:16.094ZS-EPMC99773783547040010.1093/cercor/bhac159