{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sun R"],"funding":["State Key Laboratory of Radiation Medicine and Protection","National Natural Science Foundation of China","Major Research Plan","Natural Science Foundation of Jiangsu Province"],"pagination":["2369-2378"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9977396"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(9)"],"pubmed_abstract":["Spatiotemporally manipulating the <i>in situ</i> immobilization of theranostic agents within cancer cells to improve their bioavailability is highly significant yet challenging in tumor diagnosis and treatment. Herein, as a proof-of concept, we for the first time report a tumor-targetable near-infrared (NIR) probe DACF with photoaffinity crosslinking characteristics for enhanced tumor imaging and therapeutic applications. This probe possesses great tumor-targeting capability, intensive NIR/photoacoustic (PA) signals, and a predominant photothermal effect, allowing for sensitive imaging and effective photothermal therapy (PTT) of tumors. Most notably, upon 405 nm laser illumination, DACF could be covalently immobilized within tumor cells through a photocrosslinking reaction between photolab"],"journal":["Chemical science"],"pubmed_title":["A tumor-targetable NIR probe with photoaffinity crosslinking characteristics for enhanced imaging-guided cancer phototherapy."],"pmcid":["PMC9977396"],"funding_grant_id":["GZK1202132","22077092","91959123","GZK1202140","81902913","BK20190821","GZK1202017"],"pubmed_authors":["Zhao M","Wang A","Zhu J","Sun R","Zhang Y","Gao Y","Cheng X","Shi H"],"additional_accession":[]},"is_claimable":false,"name":"A tumor-targetable NIR probe with photoaffinity crosslinking characteristics for enhanced imaging-guided cancer phototherapy.","description":"Spatiotemporally manipulating the <i>in situ</i> immobilization of theranostic agents within cancer cells to improve their bioavailability is highly significant yet challenging in tumor diagnosis and treatment. Herein, as a proof-of concept, we for the first time report a tumor-targetable near-infrared (NIR) probe DACF with photoaffinity crosslinking characteristics for enhanced tumor imaging and therapeutic applications. This probe possesses great tumor-targeting capability, intensive NIR/photoacoustic (PA) signals, and a predominant photothermal effect, allowing for sensitive imaging and effective photothermal therapy (PTT) of tumors. Most notably, upon 405 nm laser illumination, DACF could be covalently immobilized within tumor cells through a photocrosslinking reaction between photolab","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Mar","modification":"2025-04-04T20:18:14.518Z","creation":"2025-02-19T02:21:41.229Z"},"accession":"S-EPMC9977396","cross_references":{"pubmed":["36873836"],"doi":["10.1039/d2sc06413h"]}}