{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(10)"],"submitter":["Shao C"],"pubmed_abstract":["A simple and effective method for the copper-catalyzed selective C5-H bromination and difluoromethylation of 8-aminoquinoline amides with ethyl bromodifluoroacetate as the bifunctional reagent was developed. The combination of cupric catalyst and alkaline additive results in a C5-bromination reaction, whereas cuprous catalyst combined with silver additive results in the C5-difluoromethylation reaction. This method has a broad substrate scope and allows for easy and convenient access to desired C5-functionalized quinolones with good to excellent yields."],"journal":["RSC advances"],"pagination":["6993-6999"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9977446"],"repository":["biostudies-literature"],"pubmed_title":["Copper-catalyzed selective C5-H bromination and difluoromethylation of 8-aminoquinoline amides using ethyl bromodifluoroacetate as the bifunctional reagent."],"pmcid":["PMC9977446"],"pubmed_authors":["Lu M","Chen P","Zhang T","Hu Z","Hu H","Xu T","Tang C","Yang Q","Chen C","Shao C"],"additional_accession":[]},"is_claimable":false,"name":"Copper-catalyzed selective C5-H bromination and difluoromethylation of 8-aminoquinoline amides using ethyl bromodifluoroacetate as the bifunctional reagent.","description":"A simple and effective method for the copper-catalyzed selective C5-H bromination and difluoromethylation of 8-aminoquinoline amides with ethyl bromodifluoroacetate as the bifunctional reagent was developed. The combination of cupric catalyst and alkaline additive results in a C5-bromination reaction, whereas cuprous catalyst combined with silver additive results in the C5-difluoromethylation reaction. This method has a broad substrate scope and allows for easy and convenient access to desired C5-functionalized quinolones with good to excellent yields.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2025-04-04T20:18:18.032Z","creation":"2025-02-18T23:35:41.151Z"},"accession":"S-EPMC9977446","cross_references":{"pubmed":["36874938"],"doi":["10.1039/d3ra00088e"]}}