{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["615(7950)"],"submitter":["Gurtner A"],"pubmed_abstract":["In the past decade, single-cell transcriptomics has helped to uncover new cell types and states and led to the construction of a cellular compendium of health and disease. Despite this progress, some difficult-to-sequence cells remain absent from tissue atlases. Eosinophils-elusive granulocytes that are implicated in a plethora of human pathologies<sup>1-5</sup>-are among these uncharted cell types. The heterogeneity of eosinophils and the gene programs that underpin their pleiotropic functions remain poorly understood. Here we provide a comprehensive single-cell transcriptomic profiling of mouse eosinophils. We identify an active and a basal population of intestinal eosinophils, which differ in their transcriptome, surface proteome and spatial localization. By means of a genome-wide CRISP"],"journal":["Nature"],"pagination":["151-157"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9977678"],"repository":["biostudies-literature"],"pubmed_title":["Active eosinophils regulate host defence and immune responses in colitis."],"pmcid":["PMC9977678"],"pubmed_authors":["Slack E","Valenta T","Moor AE","Krebs P","Raju D","Bach K","Vu VP","Nunez NG","Becher B","Arnold IC","Gonzalez-Perez I","Borrelli C","Crepaz D","Handler K","Gschwend J","Schneider C","Gurtner A","Lafzi A","Basler K","Acar IE","Stirm K"],"additional_accession":[]},"is_claimable":false,"name":"Active eosinophils regulate host defence and immune responses in colitis.","description":"In the past decade, single-cell transcriptomics has helped to uncover new cell types and states and led to the construction of a cellular compendium of health and disease. Despite this progress, some difficult-to-sequence cells remain absent from tissue atlases. Eosinophils-elusive granulocytes that are implicated in a plethora of human pathologies<sup>1-5</sup>-are among these uncharted cell types. The heterogeneity of eosinophils and the gene programs that underpin their pleiotropic functions remain poorly understood. Here we provide a comprehensive single-cell transcriptomic profiling of mouse eosinophils. We identify an active and a basal population of intestinal eosinophils, which differ in their transcriptome, surface proteome and spatial localization. By means of a genome-wide CRISP","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Mar","modification":"2025-04-18T14:12:31.399Z","creation":"2025-04-07T00:12:56.836Z"},"accession":"S-EPMC9977678","cross_references":{"pubmed":["36509106"],"doi":["10.1038/s41586-022-05628-7"]}}