{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Nichols E"],"funding":["NIA NIH HHS","Medical Research Council","NHLBI NIH HHS","National Institute for Health Research (NIHR)","NINDS NIH HHS"],"pagination":["e115-e125"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9977689"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["4(3)"],"pubmed_abstract":["Background
Population-based autopsy studies provide valuable insights into the causes of dementia but are limited by sample size and restriction to specific populations. Harmonisation across studies increases statistical power and allows meaningful comparisons between studies. We aimed to harmonise neuropathology measures across studies and assess the prevalence, correlation, and co-occurrence of neuropathologies in the ageing population.Methods
We combined data from six community-based autopsy cohorts in the US and the UK in a coordinated cross-sectional analysis. Among all decedents aged 80 years or older, we assessed 12 neuropathologies known to be associated with dementia: arteriolosclerosis, atherosclerosis, macroinfarcts, microinfarcts, lacunes, cerebral amyloid angio"],"journal":["The lancet. Healthy longevity"],"pubmed_title":["The prevalence, correlation, and co-occurrence of neuropathology in old age: harmonisation of 12 measures across six community-based autopsy studies of dementia."],"pmcid":["PMC9977689"],"funding_grant_id":["R01 AG015819","G0900582","U19 AG066567","P30 AG066546","P30 AG010161","U01 AG006781","R01 AG017155","P30 AG066509","K08 AG065426","G0400077","UF1 NS125513","R01 NS041265","75N92019D00031","G9901400","R01 AG017917","HHSN268201500001I","U.1052.00.0013","N01HC25195","UH3 NS100599"],"pubmed_authors":["White L","Walker JM","Himali JJ","Wharton SB","Crane PK","Hunter S","Scott MR","Schneider J","Seshadri S","Keage HAD","Steinmetz JD","Wiedner CD","Brayne C","Latimer CS","Launer LJ","Matthews FE","Merrick R","Himali D","Keene CD","Hay SI","Nichols E","Vos T"],"additional_accession":[]},"is_claimable":false,"name":"The prevalence, correlation, and co-occurrence of neuropathology in old age: harmonisation of 12 measures across six community-based autopsy studies of dementia.","description":"Background
Population-based autopsy studies provide valuable insights into the causes of dementia but are limited by sample size and restriction to specific populations. Harmonisation across studies increases statistical power and allows meaningful comparisons between studies. We aimed to harmonise neuropathology measures across studies and assess the prevalence, correlation, and co-occurrence of neuropathologies in the ageing population.Methods
We combined data from six community-based autopsy cohorts in the US and the UK in a coordinated cross-sectional analysis. Among all decedents aged 80 years or older, we assessed 12 neuropathologies known to be associated with dementia: arteriolosclerosis, atherosclerosis, macroinfarcts, microinfarcts, lacunes, cerebral amyloid angio","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Mar","modification":"2025-04-21T17:04:30.121Z","creation":"2025-02-18T23:35:44.381Z"},"accession":"S-EPMC9977689","cross_references":{"pubmed":["36870337"],"doi":["10.1016/S2666-7568(23)00019-3"]}}