biostudies-literatureHwang YSAsan Institute for Life Sciences, Asan Medical Center68-78https://www.ebi.ac.uk/biostudies/studies/S-EPMC9978256biostudies-literatureUnknown16(1)<h4>Objective</h4>Depression in Parkinson's disease (PD) affects the quality of life of patients. Postural instability and gait disturbance are associated with the severity and prognosis of PD. We investigated the association of depression with axial involvement in early-stage PD patients.<h4>Methods</h4>This study involved 95 PD patients unexposed to antiparkinsonian drugs. After a baseline assessment for depression, the subjects were divided into a depressed PD group and a nondepressed PD group. Analyses were conducted to identify an association of depression at baseline with the following outcome variables: the progression to Hoehn and Yahr scale (H-Y) stage 3, the occurrence of freezing of gait (FOG), levodopa-induced dyskinesia, and wearing-off. The follow-up period was 53.40 ± 16.79 Journal of movement disordersAssociation of Depression With Early Occurrence of Postural Instability in Parkinson's Disease.PMC99782562022IT0012Lee SHwang YSPark KWChung SJLee SHJo SfalseAssociation of Depression With Early Occurrence of Postural Instability in Parkinson's Disease.<h4>Objective</h4>Depression in Parkinson's disease (PD) affects the quality of life of patients. Postural instability and gait disturbance are associated with the severity and prognosis of PD. We investigated the association of depression with axial involvement in early-stage PD patients.<h4>Methods</h4>This study involved 95 PD patients unexposed to antiparkinsonian drugs. After a baseline assessment for depression, the subjects were divided into a depressed PD group and a nondepressed PD group. Analyses were conducted to identify an association of depression at baseline with the following outcome variables: the progression to Hoehn and Yahr scale (H-Y) stage 3, the occurrence of freezing of gait (FOG), levodopa-induced dyskinesia, and wearing-off. The follow-up period was 53.40 ± 16.79 2023-01-01T00:00:00Z2023 Jan2025-04-19T09:20:02.806Z2025-04-19T09:20:02.806ZS-EPMC99782563653706510.14802/jmd.22091