{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14"],"submitter":["Meloni M"],"pubmed_abstract":["The Calvin-Benson-Bassham (CBB) cycle comprises the metabolic phase of photosynthesis and is responsible for carbon fixation and the production of sugar phosphates. The first step of the cycle involves the enzyme ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) which catalyzes the incorporation of inorganic carbon into 3-phosphoglyceric acid (3PGA). The following steps include ten enzymes that catalyze the regeneration of ribulose-1,5-bisphosphate (RuBP), the substrate of Rubisco. While it is well established that Rubisco activity acts as a limiting step of the cycle, recent modeling studies and experimental evidence have shown that the efficiency of the pathway is also impacted by the regeneration of the Rubisco substrate itself. In this work, we review the current understanding "],"journal":["Frontiers in plant science"],"pagination":["1130430"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9978339"],"repository":["biostudies-literature"],"pubmed_title":["Ribulose-1,5-bisphosphate regeneration in the Calvin-Benson-Bassham cycle: Focus on the last three enzymatic steps that allow the formation of Rubisco substrate."],"pmcid":["PMC9978339"],"pubmed_authors":["Velie L","Sparla F","Zaffagnini M","Meloni M","Fermani S","Crozet P","Gurrieri L","Henri J"],"additional_accession":[]},"is_claimable":false,"name":"Ribulose-1,5-bisphosphate regeneration in the Calvin-Benson-Bassham cycle: Focus on the last three enzymatic steps that allow the formation of Rubisco substrate.","description":"The Calvin-Benson-Bassham (CBB) cycle comprises the metabolic phase of photosynthesis and is responsible for carbon fixation and the production of sugar phosphates. The first step of the cycle involves the enzyme ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) which catalyzes the incorporation of inorganic carbon into 3-phosphoglyceric acid (3PGA). The following steps include ten enzymes that catalyze the regeneration of ribulose-1,5-bisphosphate (RuBP), the substrate of Rubisco. While it is well established that Rubisco activity acts as a limiting step of the cycle, recent modeling studies and experimental evidence have shown that the efficiency of the pathway is also impacted by the regeneration of the Rubisco substrate itself. In this work, we review the current understanding ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2025-04-21T23:51:01.217Z","creation":"2025-04-05T19:15:21.053Z"},"accession":"S-EPMC9978339","cross_references":{"pubmed":["36875598"],"doi":["10.3389/fpls.2023.1130430"]}}