biostudies-literatureUnknown6(3)Farooqui M<h4>Importance</h4>Approximately 10% to 20% of large vessel occlusion (LVO) strokes involve tandem lesions (TLs), defined as concomitant intracranial LVO and stenosis or occlusion of the cervical internal carotid artery. Mechanical thrombectomy (MT) may benefit patients with TLs; however, optimal management and procedural strategy of the cervical lesion remain unclear.<h4>Objective</h4>To evaluate the association of carotid artery stenting (CAS) vs no stenting and medical management with functional and safety outcomes among patients with TL-LVOs.<h4>Design, setting, and participants</h4>This cross-sectional study included consecutive patients with acute anterior circulation TLs admitted across 17 stroke centers in the US and Spain between January 1, 2015, and December 31, 2020. Data analysJAMA network opene230736https://www.ebi.ac.uk/biostudies/studies/S-EPMC9978940biostudies-literatureFunctional and Safety Outcomes of Carotid Artery Stenting and Mechanical Thrombectomy for Large Vessel Occlusion Ischemic Stroke With Tandem Lesions.PMC9978940Petersen NMatsoukas SMokin MMalik AMZaidat OOQureshi AIkram AAbdalkader MFarooqui MSiegler JERana AGordon WSheth SAbraham MDawod GJanjua NRingheanu VMHassan AETurabova CNguyen TNYoo AJQuispe-Orozco DZevallos CBVivanco-Suarez JKobsa JDajles AJumaa MALinares GBelow KYavagal DRGadea MOGuerrero WRSalazar-Marioni SRibo MTekle WGPrasad AGalecio-Castillo MSoomro JOrtega-Gutierrez SLin EDivani AAFifi JOliver MfalseFunctional and Safety Outcomes of Carotid Artery Stenting and Mechanical Thrombectomy for Large Vessel Occlusion Ischemic Stroke With Tandem Lesions.<h4>Importance</h4>Approximately 10% to 20% of large vessel occlusion (LVO) strokes involve tandem lesions (TLs), defined as concomitant intracranial LVO and stenosis or occlusion of the cervical internal carotid artery. Mechanical thrombectomy (MT) may benefit patients with TLs; however, optimal management and procedural strategy of the cervical lesion remain unclear.<h4>Objective</h4>To evaluate the association of carotid artery stenting (CAS) vs no stenting and medical management with functional and safety outcomes among patients with TL-LVOs.<h4>Design, setting, and participants</h4>This cross-sectional study included consecutive patients with acute anterior circulation TLs admitted across 17 stroke centers in the US and Spain between January 1, 2015, and December 31, 2020. Data analys2023-01-01T00:00:00Z2023 Mar2025-04-22T21:46:42.077Z2025-04-06T03:42:25.854ZS-EPMC99789403685705410.1001/jamanetworkopen.2023.0736