{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(2)"],"submitter":["Geng L"],"pubmed_abstract":["Ferroptosis (FPT), a novel form of programmed cell death, is characterized by overwhelming iron/reactive oxygen species (ROS)-dependent accumulation of lipid peroxidation (LPO). However, the insufficiency of endogenous iron and ROS level limited the FPT therapeutic efficacy to a large extent. To overcome this obstacle, the bromodomain-containing protein 4 (BRD<sub>4</sub>)-inhibitor (+)-JQ1 (JQ1) and iron-supplement ferric ammonium citrate (FAC)-loaded gold nanorods (GNRs) are encapsulated into the zeolitic imidazolate framework-8 (ZIF-8) to form matchbox-like GNRs@JF/ZIF-8 for the amplified FPT therapy. The existence of matchbox (ZIF-8) is stable in physiologically neutral conditions but degradable in acidic environment, which could prevent the loaded agents from prematurely reacting. Mor"],"journal":["Acta pharmaceutica Sinica. B"],"pagination":["863-878"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9979193"],"repository":["biostudies-literature"],"pubmed_title":["Iron-based and BRD<sub>4</sub>-downregulated strategy for amplified ferroptosis based on pH-sensitive/NIR-II-boosted nano-matchbox."],"pmcid":["PMC9979193"],"pubmed_authors":["Jing H","Li J","Liang X","Geng L","Lu T","Zhou Y","Li N"],"additional_accession":[]},"is_claimable":false,"name":"Iron-based and BRD<sub>4</sub>-downregulated strategy for amplified ferroptosis based on pH-sensitive/NIR-II-boosted nano-matchbox.","description":"Ferroptosis (FPT), a novel form of programmed cell death, is characterized by overwhelming iron/reactive oxygen species (ROS)-dependent accumulation of lipid peroxidation (LPO). However, the insufficiency of endogenous iron and ROS level limited the FPT therapeutic efficacy to a large extent. To overcome this obstacle, the bromodomain-containing protein 4 (BRD<sub>4</sub>)-inhibitor (+)-JQ1 (JQ1) and iron-supplement ferric ammonium citrate (FAC)-loaded gold nanorods (GNRs) are encapsulated into the zeolitic imidazolate framework-8 (ZIF-8) to form matchbox-like GNRs@JF/ZIF-8 for the amplified FPT therapy. The existence of matchbox (ZIF-8) is stable in physiologically neutral conditions but degradable in acidic environment, which could prevent the loaded agents from prematurely reacting. Mor","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2025-05-29T22:03:29.973Z","creation":"2024-11-09T06:04:23.079Z"},"accession":"S-EPMC9979193","cross_references":{"pubmed":["36873167"],"doi":["10.1016/j.apsb.2022.05.011"]}}