{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhuang K"],"funding":["NIA NIH HHS","National Institutes of Health","National Institute on Aging"],"pagination":["44-54"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9979699"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["118"],"pubmed_abstract":["We investigated self-rating of cognitive task performance (self-appraisal) and the difference between self-rating and actual task performance (appraisal discrepancy) in cognitively healthy older adults and their relationship with cortical thickness and Alzheimer's disease (AD) biomarkers, amyloid and tau. All participants (N = 151) underwent neuropsychological testing and 1.5T structural magnetic resonance imaging. A subset (N = 66) received amyloid-PET with [11C] PiB and tau-PET with [18F] Flortaucipir. We found that worse performers had lower self-appraisal ratings, but still overestimated their performance, consistent with the Dunning-Kruger effect. Self-appraisal rating and appraisal discrepancy revealed distinct relationships with cortical thickness and AD pathology. Greater appraisal discrepancy, indicating overestimation, was related to thinning of inferior-lateral temporal, fusiform, and rostral anterior cingulate cortices. Lower self-appraisal was associated with higher entorhinal and inferior temporal tau. These results suggest that overestimation could implicate structural atrophy beyond AD pathology, while lower self-appraisal could indicate early behavioral alteration due to AD pathology, supporting the notion of subjective cognitive decline prior to objective deficits."],"journal":["Neurobiology of aging"],"pubmed_title":["Metacognition, cortical thickness, and tauopathy in aging."],"pmcid":["PMC9979699"],"funding_grant_id":["AG062542","AG034570","R01 AG034570","R01 AG062542"],"pubmed_authors":["Jagust WJ","Baker SL","Chen X","Cassady KE","Zhuang K"],"additional_accession":[]},"is_claimable":false,"name":"Metacognition, cortical thickness, and tauopathy in aging.","description":"We investigated self-rating of cognitive task performance (self-appraisal) and the difference between self-rating and actual task performance (appraisal discrepancy) in cognitively healthy older adults and their relationship with cortical thickness and Alzheimer's disease (AD) biomarkers, amyloid and tau. All participants (N = 151) underwent neuropsychological testing and 1.5T structural magnetic resonance imaging. A subset (N = 66) received amyloid-PET with [11C] PiB and tau-PET with [18F] Flortaucipir. We found that worse performers had lower self-appraisal ratings, but still overestimated their performance, consistent with the Dunning-Kruger effect. Self-appraisal rating and appraisal discrepancy revealed distinct relationships with cortical thickness and AD pathology. Greater appraisal discrepancy, indicating overestimation, was related to thinning of inferior-lateral temporal, fusiform, and rostral anterior cingulate cortices. Lower self-appraisal was associated with higher entorhinal and inferior temporal tau. These results suggest that overestimation could implicate structural atrophy beyond AD pathology, while lower self-appraisal could indicate early behavioral alteration due to AD pathology, supporting the notion of subjective cognitive decline prior to objective deficits.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-04T03:00:21.347Z","creation":"2025-04-04T03:00:21.347Z"},"accession":"S-EPMC9979699","cross_references":{"pubmed":["35868093"],"doi":["10.1016/j.neurobiolaging.2022.06.007"]}}