{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11"],"submitter":["Wen J"],"funding":["The Science Foundation of Heilongjiang Province"],"pubmed_abstract":["MiR-155 and CTLA-4 are important factors involved in the regulation of immune function. However, there is no report about their involvement in function regulation of stress-induced immunosuppression affecting immune response. In this study, the chicken model of stress-induced immunosuppression affecting immune response (simulation with dexamethasone and immunization with Newcastle disease virus (NDV) attenuated vaccine) was established, then the expression characteristics of miR-155 and CTLA-4 gene were analyzed at several key time points during the processes of stress-induced immunosuppression affecting NDV vaccine immune response at serum and tissue levels. The results showed that miR-155 and CTLA-4 were the key factors involved in stress-induced immunosuppression and NDV immune response"],"journal":["PeerJ"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9979835"],"repository":["biostudies-literature"],"pubmed_title":["Stress-induced immunosuppression affecting immune response to Newcastle disease virus vaccine through “miR-155-CTLA-4” pathway in chickens"],"pmcid":["PMC9979835"],"funding_grant_id":["LH2019C073"],"pubmed_authors":["Wen J","Tian Y","Man C","Han J","Wu Y"],"additional_accession":[]},"is_claimable":false,"name":"Stress-induced immunosuppression affecting immune response to Newcastle disease virus vaccine through “miR-155-CTLA-4” pathway in chickens","description":"MiR-155 and CTLA-4 are important factors involved in the regulation of immune function. However, there is no report about their involvement in function regulation of stress-induced immunosuppression affecting immune response. In this study, the chicken model of stress-induced immunosuppression affecting immune response (simulation with dexamethasone and immunization with Newcastle disease virus (NDV) attenuated vaccine) was established, then the expression characteristics of miR-155 and CTLA-4 gene were analyzed at several key time points during the processes of stress-induced immunosuppression affecting NDV vaccine immune response at serum and tissue levels. The results showed that miR-155 and CTLA-4 were the key factors involved in stress-induced immunosuppression and NDV immune response","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2025-06-01T03:30:39.845Z","creation":"2025-02-18T23:35:41.481Z"},"accession":"S-EPMC9979835","cross_references":{}}