biostudies-literatureUnknownWaschke LNINDS NIH HHSDuring memory formation, the hippocampus is presumed to represent the content of stimuli, but how it does so is unknown. Using computational modelling and human single-neuron recordings, we show that the more precisely hippocampal spiking variability tracks the composite features of each individual stimulus, the better those stimuli are later remembered. We propose that moment-to-moment spiking variability may provide a new window into how the hippocampus constructs memories from the building blocks of our sensory world.bioRxiv : the preprint server for biology2023.02.23.529684https://www.ebi.ac.uk/biostudies/studies/S-EPMC9980052biostudies-literatureSingle-neuron spiking variability in hippocampus dynamically tracks sensory content during memory formation in humans.PMC9980052U01 NS117839Krishna SKamp Fvan den Elzen ELindenberger URutishauser UWaschke LGarrett DDfalseSingle-neuron spiking variability in hippocampus dynamically tracks sensory content during memory formation in humans.During memory formation, the hippocampus is presumed to represent the content of stimuli, but how it does so is unknown. Using computational modelling and human single-neuron recordings, we show that the more precisely hippocampal spiking variability tracks the composite features of each individual stimulus, the better those stimuli are later remembered. We propose that moment-to-moment spiking variability may provide a new window into how the hippocampus constructs memories from the building blocks of our sensory world.2024-01-01T00:00:00Z2024 Feb2025-08-15T03:07:33.275Z2025-04-04T19:17:59.64ZS-EPMC99800523686532010.1101/2023.02.23.529684