{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Naka H"],"funding":["FIC NIH HHS"],"pubmed_abstract":["<i>Teredinibacter turnerae</i> is an intracellular bacterial symbiont that resides in the gills of shipworms, wood-eating bivalve mollusks. This bacterium produces a catechol siderophore, turnerbactin, required for the survival of this bacterium under iron limiting conditions. The turnerbactin biosynthetic genes are contained in one of the secondary metabolite clusters conserved among <i>T. turnerae</i> strains. However, Fe(III)-turnerbactin uptake mechanisms are largely unknown. Here, we show that the first gene of the cluster, <i>fttA</i> a homologue of Fe(III)-siderophore TonB-dependent outer membrane receptor (TBDR) genes is indispensable for iron uptake via the endogenous siderophore, turnerbactin, as well as by an exogenous siderophore, amphi-enterobactin, ubiquitously produced by ma"],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2023.02.23.529781"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9980095"],"repository":["biostudies-literature"],"pubmed_title":["The dual role of TonB genes in turnerbactin uptake and carbohydrate utilization in the shipworm symbiont <i>Teredinibacter turnerae</i>."],"pmcid":["PMC9980095"],"funding_grant_id":["U01 TW008163"],"pubmed_authors":["Naka H","Haygood MG"],"additional_accession":[]},"is_claimable":false,"name":"The dual role of TonB genes in turnerbactin uptake and carbohydrate utilization in the shipworm symbiont <i>Teredinibacter turnerae</i>.","description":"<i>Teredinibacter turnerae</i> is an intracellular bacterial symbiont that resides in the gills of shipworms, wood-eating bivalve mollusks. This bacterium produces a catechol siderophore, turnerbactin, required for the survival of this bacterium under iron limiting conditions. The turnerbactin biosynthetic genes are contained in one of the secondary metabolite clusters conserved among <i>T. turnerae</i> strains. However, Fe(III)-turnerbactin uptake mechanisms are largely unknown. Here, we show that the first gene of the cluster, <i>fttA</i> a homologue of Fe(III)-siderophore TonB-dependent outer membrane receptor (TBDR) genes is indispensable for iron uptake via the endogenous siderophore, turnerbactin, as well as by an exogenous siderophore, amphi-enterobactin, ubiquitously produced by ma","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2026-05-09T03:15:32.235Z","creation":"2026-05-09T03:08:32.344Z"},"accession":"S-EPMC9980095","cross_references":{"pubmed":["36865190"],"doi":["10.1101/2023.02.23.529781"]}}