biostudies-literatureUnknownNaka HFIC NIH HHS<i>Teredinibacter turnerae</i> is an intracellular bacterial symbiont that resides in the gills of shipworms, wood-eating bivalve mollusks. This bacterium produces a catechol siderophore, turnerbactin, required for the survival of this bacterium under iron limiting conditions. The turnerbactin biosynthetic genes are contained in one of the secondary metabolite clusters conserved among <i>T. turnerae</i> strains. However, Fe(III)-turnerbactin uptake mechanisms are largely unknown. Here, we show that the first gene of the cluster, <i>fttA</i> a homologue of Fe(III)-siderophore TonB-dependent outer membrane receptor (TBDR) genes is indispensable for iron uptake via the endogenous siderophore, turnerbactin, as well as by an exogenous siderophore, amphi-enterobactin, ubiquitously produced by mabioRxiv : the preprint server for biology2023.02.23.529781https://www.ebi.ac.uk/biostudies/studies/S-EPMC9980095biostudies-literatureThe dual role of TonB genes in turnerbactin uptake and carbohydrate utilization in the shipworm symbiont <i>Teredinibacter turnerae</i>.PMC9980095U01 TW008163Naka HHaygood MGfalseThe dual role of TonB genes in turnerbactin uptake and carbohydrate utilization in the shipworm symbiont <i>Teredinibacter turnerae</i>.<i>Teredinibacter turnerae</i> is an intracellular bacterial symbiont that resides in the gills of shipworms, wood-eating bivalve mollusks. This bacterium produces a catechol siderophore, turnerbactin, required for the survival of this bacterium under iron limiting conditions. The turnerbactin biosynthetic genes are contained in one of the secondary metabolite clusters conserved among <i>T. turnerae</i> strains. However, Fe(III)-turnerbactin uptake mechanisms are largely unknown. Here, we show that the first gene of the cluster, <i>fttA</i> a homologue of Fe(III)-siderophore TonB-dependent outer membrane receptor (TBDR) genes is indispensable for iron uptake via the endogenous siderophore, turnerbactin, as well as by an exogenous siderophore, amphi-enterobactin, ubiquitously produced by ma2023-01-01T00:00:00Z2023 Feb2026-05-09T03:15:32.235Z2026-05-09T03:08:32.344ZS-EPMC99800953686519010.1101/2023.02.23.529781