{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Datta S"],"funding":["NEI NIH HHS","National Institutes of Health"],"pagination":["966-983"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9980637"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(3)"],"pubmed_abstract":["Age-related macular degeneration (AMD), the leading cause of blindness among the elderly, is without treatment for early disease. Degenerative retinal pigment epithelial (RPE) cell heterogeneity is a well-recognized but understudied pathogenic factor. Due to the daily phagocytosis of photoreceptor outer segments, unique photo-oxidative stress, and high metabolism for maintaining vision, the RPE has robust macroautophagy/autophagy, and mitochondrial and antioxidant networks. However, the autophagy subtype, mitophagy, in the RPE and AMD is understudied. Here, we found decreased PINK1 (PTEN induced kinase 1) in perifoveal RPE of early AMD eyes. PINK1-deficient RPE have impaired mitophagy and mitochondrial function that triggers death-resistant epithelial-mesenchymal transition (EMT). This rep"],"journal":["Autophagy"],"pubmed_title":["Mitophagy initiates retrograde mitochondrial-nuclear signaling to guide retinal pigment cell heterogeneity."],"pmcid":["PMC9980637"],"funding_grant_id":["R00 EY029010","P30 EY006360","P30 EY008098","R01 EY033765","R01 EY027691","P30 EY001765","R01 EY031594","K99 EY029010"],"pubmed_authors":["Qian J","Sinha D","Itoh K","Handa JT","Liu T","Wang J","Wang L","Kannan R","Datta S","Sharma A","Cano M","Satyanarayana G","Bhutto I","Cheng J"],"additional_accession":[]},"is_claimable":false,"name":"Mitophagy initiates retrograde mitochondrial-nuclear signaling to guide retinal pigment cell heterogeneity.","description":"Age-related macular degeneration (AMD), the leading cause of blindness among the elderly, is without treatment for early disease. Degenerative retinal pigment epithelial (RPE) cell heterogeneity is a well-recognized but understudied pathogenic factor. Due to the daily phagocytosis of photoreceptor outer segments, unique photo-oxidative stress, and high metabolism for maintaining vision, the RPE has robust macroautophagy/autophagy, and mitochondrial and antioxidant networks. However, the autophagy subtype, mitophagy, in the RPE and AMD is understudied. Here, we found decreased PINK1 (PTEN induced kinase 1) in perifoveal RPE of early AMD eyes. PINK1-deficient RPE have impaired mitophagy and mitochondrial function that triggers death-resistant epithelial-mesenchymal transition (EMT). This rep","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Mar","modification":"2025-04-04T20:04:51.894Z","creation":"2025-04-04T20:04:51.894Z"},"accession":"S-EPMC9980637","cross_references":{"pubmed":["35921555"],"doi":["10.1080/15548627.2022.2109286"]}}