biostudies-literatureUnknown10Hung KC<h4>Background</h4>Although post-stroke depression (PSD) affects one-third of patients following an acute stroke, pooled evidence addressing the correlation between a low vitamin D status and the risk of PSD remains inconclusive.<h4>Methods</h4>Comprehensive database search of Medline, EMBASE, Cochrane library, and Google Scholar was performed from inception to December 2022. The primary outcome was the association of PSD risk with a low vitamin D status, while the secondary outcomes included the relationship between PSD and other risk factors.<h4>Results</h4>Analysis of seven observational studies published between 2014 and 2022 with 1,580 patients showed pooled incidences of vitamin D deficiency (defined as 25[OH] D levels < 50 nmol/L) and PSD of 60.1 and 26.1%, respectively. Patients wiFrontiers in nutrition1142035https://www.ebi.ac.uk/biostudies/studies/S-EPMC9983120biostudies-literatureAssociation of a low vitamin D status with risk of post-stroke depression: A meta-analysis and systematic review.PMC9983120Illias AMChang YJHung KCChiu CCLiao SWWang KFSun CKChen IWWu JYfalseAssociation of a low vitamin D status with risk of post-stroke depression: A meta-analysis and systematic review.<h4>Background</h4>Although post-stroke depression (PSD) affects one-third of patients following an acute stroke, pooled evidence addressing the correlation between a low vitamin D status and the risk of PSD remains inconclusive.<h4>Methods</h4>Comprehensive database search of Medline, EMBASE, Cochrane library, and Google Scholar was performed from inception to December 2022. The primary outcome was the association of PSD risk with a low vitamin D status, while the secondary outcomes included the relationship between PSD and other risk factors.<h4>Results</h4>Analysis of seven observational studies published between 2014 and 2022 with 1,580 patients showed pooled incidences of vitamin D deficiency (defined as 25[OH] D levels < 50 nmol/L) and PSD of 60.1 and 26.1%, respectively. Patients wi2023-01-01T00:00:00Z20232025-04-04T11:35:42.451Z2025-04-04T11:35:42.451ZS-EPMC99831203687585310.3389/fnut.2023.1142035