{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Shuping JL"],"funding":["NIA NIH HHS"],"pagination":["e12372"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9983143"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(1)"],"pubmed_abstract":["<h4>Background</h4>The positron emission tomography (PET) radiotracer [<sup>18</sup>F]MK-6240 exhibits high specificity for neurofibrillary tangles (NFTs) of tau protein in Alzheimer's disease (AD), high sensitivity to medial temporal and neocortical NFTs, and low within-brain background. Objectives were to develop and validate a reproducible, clinically relevant visual read method supporting [<sup>18</sup>F]MK-6240 use to identify and stage AD subjects versus non-AD and controls.<h4>Methods</h4>Five expert readers used their own methods to assess 30 scans of mixed diagnosis (47% cognitively normal, 23% mild cognitive impairment, 20% AD, 10% traumatic brain injury) and provided input regarding regional and global positivity, features influencing assessment, confidence, practicality, and cl"],"journal":["Alzheimer's & dementia (New York, N. Y.)"],"pubmed_title":["Development, initial validation, and application of a visual read method for [<sup>18</sup>F]MK-6240 tau PET."],"pmcid":["PMC9983143"],"funding_grant_id":["RF1 AG058067","K24 AG045334","R01 AG050436","R01 AG052414","R01 AG038465","R01 AG055299","R01 AG050440","P30 AG062715","RF1 AG051556","R01 AG055422","R01 AG062285","P01 AG025204","K23 AG052633","RF1 AG027161","R01 AG021155","R01 AG063888","R00 AG065506","R01 AG062167"],"pubmed_authors":["Wilde CL","Klunk WE","Scott D","Brickman AM","Lukic AS","Ward L","Mathotaarachchi SS","Rowe CC","Devanand DP","Johnson SC","Johnson KA","Boxer AL","Lao PJ","Sur C","Price JC","Cordes L","Rosa-Neto P","Stern Y","Luchsinger JA","Andrews RD","Van Laere K","Evelhoch JL","Barakos J","Kreisl WC","Purcell DD","Matthews DC","Shuping JL","Adamczuk K"],"additional_accession":[]},"is_claimable":false,"name":"Development, initial validation, and application of a visual read method for [<sup>18</sup>F]MK-6240 tau PET.","description":"<h4>Background</h4>The positron emission tomography (PET) radiotracer [<sup>18</sup>F]MK-6240 exhibits high specificity for neurofibrillary tangles (NFTs) of tau protein in Alzheimer's disease (AD), high sensitivity to medial temporal and neocortical NFTs, and low within-brain background. Objectives were to develop and validate a reproducible, clinically relevant visual read method supporting [<sup>18</sup>F]MK-6240 use to identify and stage AD subjects versus non-AD and controls.<h4>Methods</h4>Five expert readers used their own methods to assess 30 scans of mixed diagnosis (47% cognitively normal, 23% mild cognitive impairment, 20% AD, 10% traumatic brain injury) and provided input regarding regional and global positivity, features influencing assessment, confidence, practicality, and cl","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan-Mar","modification":"2026-03-17T15:23:46.683Z","creation":"2025-08-16T03:06:32.324Z"},"accession":"S-EPMC9983143","cross_references":{"pubmed":["36873926"],"doi":["10.1002/trc2.12372"]}}