biostudies-literatureUnknown10Ndlovu ISNeurosurgical Research Foundation<i>Trichinella</i> infections have been documented globally and have been detected in wild and/or domestic animals except Antarctica. There is paucity of information in the metabolic responses of hosts during <i>Trichinella</i> infections and biomarkers for infection that can be used in the diagnosis of the disease. The current study aimed to apply a non-targeted metabolomic approach to identify <i>Trichinella zimbabwensis</i> biomarkers including metabolic response from sera of infected Sprague-Dawley rats. Fifty-four male Sprague-Dawley rats were randomly assigned into <i>T. zimbabwensis</i> infected group (<i>n</i> = 36) and the non-infected control (<i>n</i> = 18). Results from the study showed that the metabolic signature of <i>T. zimbabwensis</i> infection consists of enriched methylFrontiers in molecular biosciences1128542https://www.ebi.ac.uk/biostudies/studies/S-EPMC9983363biostudies-literaturePreliminary insights on the metabolomics of <i>Trichinella zimbabwensis</i> infection in Sprague Dawley rats using GCxGC-TOF-MS (untargeted approach).PMC9983363Mukaratirwa SChaisi MNdlovu ISSilas ETshilwane SIVosloo AfalsePreliminary insights on the metabolomics of <i>Trichinella zimbabwensis</i> infection in Sprague Dawley rats using GCxGC-TOF-MS (untargeted approach).<i>Trichinella</i> infections have been documented globally and have been detected in wild and/or domestic animals except Antarctica. There is paucity of information in the metabolic responses of hosts during <i>Trichinella</i> infections and biomarkers for infection that can be used in the diagnosis of the disease. The current study aimed to apply a non-targeted metabolomic approach to identify <i>Trichinella zimbabwensis</i> biomarkers including metabolic response from sera of infected Sprague-Dawley rats. Fifty-four male Sprague-Dawley rats were randomly assigned into <i>T. zimbabwensis</i> infected group (<i>n</i> = 36) and the non-infected control (<i>n</i> = 18). Results from the study showed that the metabolic signature of <i>T. zimbabwensis</i> infection consists of enriched methyl2023-01-01T00:00:00Z20232025-08-15T03:05:41.875Z2025-05-29T16:30:31.952ZS-EPMC99833633687604510.3389/fmolb.2023.1128542