{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(1)"],"submitter":["Ravindra KC"],"pubmed_abstract":["Diagnosis of drug-induced liver injury (DILI) and its distinction from other liver diseases are significant challenges in drug development and clinical practice. Here, we identify, confirm, and replicate the biomarker performance characteristics of candidate proteins in patients with DILI at onset (DO; n = 133) and follow-up (n = 120), acute non-DILI at onset (NDO; n = 63) and follow-up (n = 42), and healthy volunteers (HV; n = 104). Area under the receiver operating characteristic curve (AUC) for cytoplasmic aconitate hydratase, argininosuccinate synthase, carbamoylphosphate synthase, fumarylacetoacetase, fructose-1,6-bisphosphatase 1 (FBP1) across cohorts achieved near complete separation (range: 0.94-0.99) of DO and HV. In addition, we show that FBP1, alone or in combination with glutat"],"journal":["Nature communications"],"pagination":["1215"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9984368"],"repository":["biostudies-literature"],"pubmed_title":["Tandem mass tag-based quantitative proteomic profiling identifies candidate serum biomarkers of drug-induced liver injury in humans."],"pmcid":["PMC9984368"],"pubmed_authors":["Virgen-Slane R","Bjornsson ES","Stephens C","Aithal GP","Ramaiah SK","Dear JW","Vaidya VS","Isabel Lucena M","Hussaini H","Wang Z","Grove JI","Patel J","Ocana MF","Verma S","Hyde C","Robles-Diaz M","Everley RA","Cortez-Pinto H","Fowell AJ","Elsharkawy AM","Stirnimann G","Andrade RJ","Ravindra KC","Atallah E","Federspiel JD","Weber S","Griffiths WJH","Gerbes AL"],"additional_accession":[]},"is_claimable":false,"name":"Tandem mass tag-based quantitative proteomic profiling identifies candidate serum biomarkers of drug-induced liver injury in humans.","description":"Diagnosis of drug-induced liver injury (DILI) and its distinction from other liver diseases are significant challenges in drug development and clinical practice. Here, we identify, confirm, and replicate the biomarker performance characteristics of candidate proteins in patients with DILI at onset (DO; n = 133) and follow-up (n = 120), acute non-DILI at onset (NDO; n = 63) and follow-up (n = 42), and healthy volunteers (HV; n = 104). Area under the receiver operating characteristic curve (AUC) for cytoplasmic aconitate hydratase, argininosuccinate synthase, carbamoylphosphate synthase, fumarylacetoacetase, fructose-1,6-bisphosphatase 1 (FBP1) across cohorts achieved near complete separation (range: 0.94-0.99) of DO and HV. In addition, we show that FBP1, alone or in combination with glutat","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Mar","modification":"2025-05-29T16:30:25.004Z","creation":"2025-04-06T12:22:04.717Z"},"accession":"S-EPMC9984368","cross_references":{"pubmed":["36869085"],"doi":["10.1038/s41467-023-36858-6"]}}