biostudies-literatureUnknown13(1)Iwasaki THeight loss is caused by osteoporosis, vertebral fractures, disc reduction, postural changes, and kyphosis. Marked long-term height loss is reportedly associated with cardiovascular disease and mortality in the elderly. The present study investigated the relationship between short-term height loss and the risk of mortality using the longitudinal cohort data of the Japan Specific Health Checkup Study (J-SHC). Included individuals were aged 40 years or older and received periodic health checkups in 2008 and 2010. The exposure of interest was height loss over the 2 years, and the outcome was all-cause mortality over subsequent follow up. Cox proportional hazard models were used to examine the association between height loss and all-cause mortality. Of the 222,392 individuals (88,285 men, 134,Scientific reports3593https://www.ebi.ac.uk/biostudies/studies/S-EPMC9984491biostudies-literatureAssociation between height loss and mortality in the general population.PMC9984491Kasahara MIwasaki TAsahi KIseki KWatanabe TKazama JJFujimoto STsuruya KKonta TYamagata KShibagaki YKimura HMoriyama TKondo MTanaka KNarita IfalseAssociation between height loss and mortality in the general population.Height loss is caused by osteoporosis, vertebral fractures, disc reduction, postural changes, and kyphosis. Marked long-term height loss is reportedly associated with cardiovascular disease and mortality in the elderly. The present study investigated the relationship between short-term height loss and the risk of mortality using the longitudinal cohort data of the Japan Specific Health Checkup Study (J-SHC). Included individuals were aged 40 years or older and received periodic health checkups in 2008 and 2010. The exposure of interest was height loss over the 2 years, and the outcome was all-cause mortality over subsequent follow up. Cox proportional hazard models were used to examine the association between height loss and all-cause mortality. Of the 222,392 individuals (88,285 men, 134,2023-01-01T00:00:00Z2023 Mar2025-05-29T22:03:09.576Z2025-05-29T22:03:09.576ZS-EPMC99844913686915410.1038/s41598-023-30835-1