{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tong X"],"funding":["National Natural Science Foundation of China","Special Project for Research and Development in Key areas of Guangdong Province","Changsha Science and Technology Project"],"pagination":["100-112"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9984782"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["39"],"pubmed_abstract":["<h4>Background</h4>The inadequate regeneration of natural tissue (mainly fibrocartilage) between tendon and bone during rotator cuff (RC) repair results in an unsatisfactory quality of RC healing. Cell-free therapy based on stem cell exosomes is a safer and more promising approach for tissue regeneration. Here, we investigated the effect of exosomes from human urine-derived stem cells (USCs) and their subpopulations (CD133<sup>+</sup>USCs) on RC healing.<h4>Methods</h4>USCs were isolated from urine and sorted by flow cytometry to obtain CD133<sup>+</sup> urine-derived stem cells (CD133<sup>+</sup> USCs). Urine-derived stem cell exosomes (USC-Exos) and CD133<sup>+</sup> urine-derived stem cell exosomes (CD133<sup>+</sup> USC-Exos) were subsequently isolated from the cell supernatant and ide"],"journal":["Journal of orthopaedic translation"],"pubmed_title":["Exosomes from CD133<sup>+</sup> human urine-derived stem cells combined adhesive hydrogel facilitate rotator cuff healing by mediating bone marrow mesenchymal stem cells."],"pmcid":["PMC9984782"],"funding_grant_id":["kh2102015","81730068","81974338","2020SK2077"],"pubmed_authors":["Deng C","Zhang T","Xun J","Sun D","Xu D","Tong X","Xu Y"],"additional_accession":[]},"is_claimable":false,"name":"Exosomes from CD133<sup>+</sup> human urine-derived stem cells combined adhesive hydrogel facilitate rotator cuff healing by mediating bone marrow mesenchymal stem cells.","description":"<h4>Background</h4>The inadequate regeneration of natural tissue (mainly fibrocartilage) between tendon and bone during rotator cuff (RC) repair results in an unsatisfactory quality of RC healing. Cell-free therapy based on stem cell exosomes is a safer and more promising approach for tissue regeneration. Here, we investigated the effect of exosomes from human urine-derived stem cells (USCs) and their subpopulations (CD133<sup>+</sup>USCs) on RC healing.<h4>Methods</h4>USCs were isolated from urine and sorted by flow cytometry to obtain CD133<sup>+</sup> urine-derived stem cells (CD133<sup>+</sup> USCs). Urine-derived stem cell exosomes (USC-Exos) and CD133<sup>+</sup> urine-derived stem cell exosomes (CD133<sup>+</sup> USC-Exos) were subsequently isolated from the cell supernatant and ide","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Mar","modification":"2025-04-04T11:35:48.035Z","creation":"2025-04-04T11:35:48.035Z"},"accession":"S-EPMC9984782","cross_references":{"pubmed":["36879794"],"doi":["10.1016/j.jot.2023.02.002"]}}