{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chen C"],"funding":["the Key Research and Development (R&amp;D) Projects of Shaanxi Province"],"pagination":["41"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9985208"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["<h4>Background</h4>Previous observational studies have shown an association between asthma, atopic dermatitis (AD) and rheumatoid arthritis (RA). However, the bidirectional cause-effect chain between asthma and AD and RA has not been proven yet.<h4>Methods</h4>We performed bidirectional two-sample Mendelian randomization (TSMR) and selected single nucleotide polymorphisms (SNPs) associated with asthma, AD, and RA as instrumental variables. All of the SNPs were obtained from the latest genome-wide association study in Europeans. Inverse variance weighted (IVW) was the main method used in MR analysis. MR-Egger, weighted model, simple model, and weighted median were used for quality control. The robustness of the results was tested by sensitivity analysis.<h4>Results</h4>Asthma was found to b"],"journal":["BMC medical genomics"],"pubmed_title":["Asthma and atopic dermatitis as risk factors for rheumatoid arthritis: a bidirectional mendelian randomization study."],"pmcid":["PMC9985208"],"funding_grant_id":["2022SF-074","No. 2022SF-074"],"pubmed_authors":["Zheng Y","Zhang D","Su L","Chen C","Wang Y","Duan W"],"additional_accession":[]},"is_claimable":false,"name":"Asthma and atopic dermatitis as risk factors for rheumatoid arthritis: a bidirectional mendelian randomization study.","description":"<h4>Background</h4>Previous observational studies have shown an association between asthma, atopic dermatitis (AD) and rheumatoid arthritis (RA). However, the bidirectional cause-effect chain between asthma and AD and RA has not been proven yet.<h4>Methods</h4>We performed bidirectional two-sample Mendelian randomization (TSMR) and selected single nucleotide polymorphisms (SNPs) associated with asthma, AD, and RA as instrumental variables. All of the SNPs were obtained from the latest genome-wide association study in Europeans. Inverse variance weighted (IVW) was the main method used in MR analysis. MR-Egger, weighted model, simple model, and weighted median were used for quality control. The robustness of the results was tested by sensitivity analysis.<h4>Results</h4>Asthma was found to b","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Mar","modification":"2025-04-22T12:01:16.851Z","creation":"2025-04-06T00:07:17.659Z"},"accession":"S-EPMC9985208","cross_references":{"pubmed":["36869337"],"doi":["10.1186/s12920-023-01461-7"]}}