biostudies-literatureChen Cthe Key Research and Development (R&amp;D) Projects of Shaanxi Province41https://www.ebi.ac.uk/biostudies/studies/S-EPMC9985208biostudies-literatureUnknown16(1)<h4>Background</h4>Previous observational studies have shown an association between asthma, atopic dermatitis (AD) and rheumatoid arthritis (RA). However, the bidirectional cause-effect chain between asthma and AD and RA has not been proven yet.<h4>Methods</h4>We performed bidirectional two-sample Mendelian randomization (TSMR) and selected single nucleotide polymorphisms (SNPs) associated with asthma, AD, and RA as instrumental variables. All of the SNPs were obtained from the latest genome-wide association study in Europeans. Inverse variance weighted (IVW) was the main method used in MR analysis. MR-Egger, weighted model, simple model, and weighted median were used for quality control. The robustness of the results was tested by sensitivity analysis.<h4>Results</h4>Asthma was found to bBMC medical genomicsAsthma and atopic dermatitis as risk factors for rheumatoid arthritis: a bidirectional mendelian randomization study.PMC99852082022SF-074No. 2022SF-074Zheng YZhang DSu LChen CWang YDuan WfalseAsthma and atopic dermatitis as risk factors for rheumatoid arthritis: a bidirectional mendelian randomization study.<h4>Background</h4>Previous observational studies have shown an association between asthma, atopic dermatitis (AD) and rheumatoid arthritis (RA). However, the bidirectional cause-effect chain between asthma and AD and RA has not been proven yet.<h4>Methods</h4>We performed bidirectional two-sample Mendelian randomization (TSMR) and selected single nucleotide polymorphisms (SNPs) associated with asthma, AD, and RA as instrumental variables. All of the SNPs were obtained from the latest genome-wide association study in Europeans. Inverse variance weighted (IVW) was the main method used in MR analysis. MR-Egger, weighted model, simple model, and weighted median were used for quality control. The robustness of the results was tested by sensitivity analysis.<h4>Results</h4>Asthma was found to b2023-01-01T00:00:00Z2023 Mar2025-04-22T12:01:16.851Z2025-04-06T00:07:17.659ZS-EPMC99852083686933710.1186/s12920-023-01461-7