biostudies-literatureJohnson SAAmyotrophic Lateral Sclerosis Association (ALS Association)34https://www.ebi.ac.uk/biostudies/studies/S-EPMC9987377biostudies-literatureUnknown6(1)Amyotrophic lateral sclerosis (ALS) therapeutic development has largely relied on staff-administered functional rating scales to determine treatment efficacy. We sought to determine if mobile applications (apps) and wearable devices can be used to quantify ALS disease progression through active (surveys) and passive (sensors) data collection. Forty ambulatory adults with ALS were followed for 6-months. The Beiwe app was used to administer the self-entry ALS functional rating scale-revised (ALSFRS-RSE) and the Rasch Overall ALS Disability Scale (ROADS) surveys every 2-4 weeks. Each participant used a wrist-worn activity monitor (ActiGraph Insight Watch) or an ankle-worn activity monitor (Modus StepWatch) continuously. Wearable device wear and app survey compliance were adequate. ALSFRS-R hiNPJ digital medicineWearable device and smartphone data quantify ALS progression and may provide novel outcome measures.PMC998737722-PDF-604Iwasaki SIyer ASClark APKaras MBurke KMStraczkiewicz MScheier ZAJohnson SABerry JDLahav AOnnela JPfalseWearable device and smartphone data quantify ALS progression and may provide novel outcome measures.Amyotrophic lateral sclerosis (ALS) therapeutic development has largely relied on staff-administered functional rating scales to determine treatment efficacy. We sought to determine if mobile applications (apps) and wearable devices can be used to quantify ALS disease progression through active (surveys) and passive (sensors) data collection. Forty ambulatory adults with ALS were followed for 6-months. The Beiwe app was used to administer the self-entry ALS functional rating scale-revised (ALSFRS-RSE) and the Rasch Overall ALS Disability Scale (ROADS) surveys every 2-4 weeks. Each participant used a wrist-worn activity monitor (ActiGraph Insight Watch) or an ankle-worn activity monitor (Modus StepWatch) continuously. Wearable device wear and app survey compliance were adequate. ALSFRS-R hi2023-01-01T00:00:00Z2023 Mar2025-04-21T19:49:23.399Z2025-02-19T02:21:51.773ZS-EPMC99873773687902510.1038/s41746-023-00778-y