biostudies-literatureUnknownCiccozzi MSapienza Università di RomaThe SARS-CoV-2 Spike receptor binding domain and N-terminal domain interact with each other in an intricate mechanism. Mutations modulate the interplay between the Spike and host molecules. This editorial comments on the intricacies of SARS-CoV-2 Spike interactions.Future virologyhttps://www.ebi.ac.uk/biostudies/studies/S-EPMC9987531biostudies-literatureTwo sides of the same coin: the N-terminal and the receptor binding domains of SARS-CoV-2 Spike.PMC9987531RP12117A7670A1E8Pascarella SCiccozzi MfalseTwo sides of the same coin: the N-terminal and the receptor binding domains of SARS-CoV-2 Spike.The SARS-CoV-2 Spike receptor binding domain and N-terminal domain interact with each other in an intricate mechanism. Mutations modulate the interplay between the Spike and host molecules. This editorial comments on the intricacies of SARS-CoV-2 Spike interactions.2023-01-01T00:00:00Z2023 Feb2024-11-15T19:18:41.475Z2024-11-15T19:18:41.475ZS-EPMC99875313689614510.2217/fvl-2022-0181