biostudies-literatureAbioye AIEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentNICHD NIH HHSNIDDK NIH HHS987-1001https://www.ebi.ac.uk/biostudies/studies/S-EPMC9987582biostudies-literatureUnknown62(2)<h4>Purpose</h4>Whether anemia type modifies the risk of pregnancy and newborn outcomes and the effectiveness of iron supplementation is unclear. We examined the association of iron deficiency anemia (IDA) and non-iron deficiency anemia (NIDA) on the risks of these outcomes and the extent to which anemia type modifies the impact of prenatal iron supplementation.<h4>Methods</h4>This was a secondary analysis of a placebo-controlled trial of iron supplementation among 1450 HIV-negative women in Tanzania. Eligibility criteria included gestational age < 27 weeks, hemoglobin > 85 g/L, and ferritin > 12 µg/L. Individuals were categorized as non-anemia, IDA or NIDA using hemoglobin, ferritin and CRP. Analyses were conducted using regression models and likelihood ratio tests.<h4>Results</h4>CompareEuropean journal of nutritionThe effect of iron supplementation on maternal iron deficiency anemia does not differ by baseline anemia type among Tanzanian pregnant women without severe iron deficiency anemia.PMC9987582U01 HD061232K24 DK104676P30 DK040561Aboud SFawzi WWAbioye AISudfeld CRHamer DHDuggan CPPremji ZHughes MDRoberts DJfalseThe effect of iron supplementation on maternal iron deficiency anemia does not differ by baseline anemia type among Tanzanian pregnant women without severe iron deficiency anemia.<h4>Purpose</h4>Whether anemia type modifies the risk of pregnancy and newborn outcomes and the effectiveness of iron supplementation is unclear. We examined the association of iron deficiency anemia (IDA) and non-iron deficiency anemia (NIDA) on the risks of these outcomes and the extent to which anemia type modifies the impact of prenatal iron supplementation.<h4>Methods</h4>This was a secondary analysis of a placebo-controlled trial of iron supplementation among 1450 HIV-negative women in Tanzania. Eligibility criteria included gestational age < 27 weeks, hemoglobin > 85 g/L, and ferritin > 12 µg/L. Individuals were categorized as non-anemia, IDA or NIDA using hemoglobin, ferritin and CRP. Analyses were conducted using regression models and likelihood ratio tests.<h4>Results</h4>Compare2023-01-01T00:00:00Z2023 Mar2026-06-02T19:25:51.016Z2025-04-04T20:40:55.297ZS-EPMC99875823634477010.1007/s00394-022-03029-0