biostudies-literatureUnknown15(1)Pascual JLacer S.A.<h4>Background</h4>Many antimicrobial compounds in mouthwashes can have a negative impact on the oral microbiome. O-cymen-5-ol, a compound derived from a phytochemical, has a targeted mode of action and is being used as an alternative. However, its effect on the native oral microbiome is unknown.<h4>Aim</h4>To assess the effect of a mouthwash formulated with o-cymen-5-ol and zinc chloride on the oral microbiome of healthy individuals.<h4>Methods</h4>A mouthwash formulated with o-cymen-5-ol and zinc chloride was administered to a cohort of 51 volunteers for 14 days, while another cohort of 49 volunteers received a placebo. The evolution of the oral microbiome in both groups was analysed using a metataxonomic approach.<h4>Results</h4>Analysis of the oral microbiome showed that the mouthwash Journal of oral microbiology2185962https://www.ebi.ac.uk/biostudies/studies/S-EPMC9987754biostudies-literatureA mouthwash formulated with o-cymen-5-ol and zinc chloride specifically targets potential pathogens without impairing the native oral microbiome in healthy individuals.PMC9987754Vivancos Cuadras FMira Otal JPorcar MPascual JTorrent-Silla DVilanova CfalseA mouthwash formulated with o-cymen-5-ol and zinc chloride specifically targets potential pathogens without impairing the native oral microbiome in healthy individuals.<h4>Background</h4>Many antimicrobial compounds in mouthwashes can have a negative impact on the oral microbiome. O-cymen-5-ol, a compound derived from a phytochemical, has a targeted mode of action and is being used as an alternative. However, its effect on the native oral microbiome is unknown.<h4>Aim</h4>To assess the effect of a mouthwash formulated with o-cymen-5-ol and zinc chloride on the oral microbiome of healthy individuals.<h4>Methods</h4>A mouthwash formulated with o-cymen-5-ol and zinc chloride was administered to a cohort of 51 volunteers for 14 days, while another cohort of 49 volunteers received a placebo. The evolution of the oral microbiome in both groups was analysed using a metataxonomic approach.<h4>Results</h4>Analysis of the oral microbiome showed that the mouthwash 2023-01-01T00:00:00Z20232026-05-28T11:30:56.014Z2025-04-07T03:19:37.557ZS-EPMC99877543689119410.1080/20002297.2023.2185962