{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["56(9)"],"submitter":["Marinelli C"],"pubmed_abstract":["<h4>Background/goal</h4>Ulcerative colitis (UC) is characterized by chronic inflammation and progressive course, with potential extraintestinal complications including cardiovascular mortality. Serum proprotein convertase subtilisin/kexin type 9 (PCSK9) levels have been recently recognized as biomarkers of low-grade inflammation and cardiovascular disease. The aim of our study was to evaluate PCSK9 levels in patients with UC and different degrees of disease activity.<h4>Methods</h4>We prospectively recruited consecutive patients with UC attending our center at the University Hospital of Padua. Demographics, clinical characteristics, and biochemical data, including PCSK9, high sensitivity C-reactive protein, and fecal calprotectin, were recorded. Moreover, endoscopic procedures were perform"],"journal":["Journal of clinical gastroenterology"],"pagination":["787-793"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9988229"],"repository":["biostudies-literature"],"pubmed_title":["Serum Levels of PCSK9 Are Increased in Patients With Active Ulcerative Colitis Representing a Potential Biomarker of Disease Activity: A Cross-sectional Study."],"pmcid":["PMC9988229"],"pubmed_authors":["Casadei C","Ferri N","Gubbiotti A","Barberio B","Marinelli C","Marin R","D'Inca R","Massimi D","Zingone F","Savarino E","Lupo MG"],"additional_accession":[]},"is_claimable":false,"name":"Serum Levels of PCSK9 Are Increased in Patients With Active Ulcerative Colitis Representing a Potential Biomarker of Disease Activity: A Cross-sectional Study.","description":"<h4>Background/goal</h4>Ulcerative colitis (UC) is characterized by chronic inflammation and progressive course, with potential extraintestinal complications including cardiovascular mortality. Serum proprotein convertase subtilisin/kexin type 9 (PCSK9) levels have been recently recognized as biomarkers of low-grade inflammation and cardiovascular disease. The aim of our study was to evaluate PCSK9 levels in patients with UC and different degrees of disease activity.<h4>Methods</h4>We prospectively recruited consecutive patients with UC attending our center at the University Hospital of Padua. Demographics, clinical characteristics, and biochemical data, including PCSK9, high sensitivity C-reactive protein, and fecal calprotectin, were recorded. Moreover, endoscopic procedures were perform","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-21T19:43:18.258Z","creation":"2025-02-19T02:21:57.95Z"},"accession":"S-EPMC9988229","cross_references":{"pubmed":["34560758"],"doi":["10.1097/MCG.0000000000001607"]}}