{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Naderi E"],"funding":["NIDCD NIH HHS"],"pagination":["1106328"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9988903"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14"],"pubmed_abstract":["Age-related (AR) hearing loss (HL) is the most common sensory impairment with heritability of 55%. The aim of this study was to identify genetic variants on chromosome X associated with ARHL through the analysis of data obtained from the UK Biobank. We performed association analysis between self-reported measures of HL and genotyped and imputed variants on chromosome X from ∼460,000 white Europeans. We identified three loci associated with ARHL with a genome-wide significance level (p < 5 × 10<sup>-8</sup>), <i>ZNF185</i> (rs186256023, <i>p</i> = 4.9 × 10<sup>-10</sup>) and <i>MAP7D2</i> (rs4370706, <i>p</i> = 2.3 × 10<sup>-8</sup>) in combined analysis of males and females, and <i>LOC101928437</i> (rs138497700, <i>p</i> = 8.9 × 10<sup>-9</sup>) in the sex-stratified analysis of males. <i>"],"journal":["Frontiers in genetics"],"pubmed_title":["The genetic contribution of the X chromosome in age-related hearing loss."],"pmcid":["PMC9988903"],"funding_grant_id":["R01 DC017712"],"pubmed_authors":["Li G","Naderi E","Schrauwen I","Wang GT","Leal SM","Cornejo-Sanchez DM","Dewan AT"],"additional_accession":[]},"is_claimable":false,"name":"The genetic contribution of the X chromosome in age-related hearing loss.","description":"Age-related (AR) hearing loss (HL) is the most common sensory impairment with heritability of 55%. The aim of this study was to identify genetic variants on chromosome X associated with ARHL through the analysis of data obtained from the UK Biobank. We performed association analysis between self-reported measures of HL and genotyped and imputed variants on chromosome X from ∼460,000 white Europeans. We identified three loci associated with ARHL with a genome-wide significance level (p < 5 × 10<sup>-8</sup>), <i>ZNF185</i> (rs186256023, <i>p</i> = 4.9 × 10<sup>-10</sup>) and <i>MAP7D2</i> (rs4370706, <i>p</i> = 2.3 × 10<sup>-8</sup>) in combined analysis of males and females, and <i>LOC101928437</i> (rs138497700, <i>p</i> = 8.9 × 10<sup>-9</sup>) in the sex-stratified analysis of males. <i>","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2026-05-13T14:35:12.808Z","creation":"2025-02-19T03:26:17.443Z"},"accession":"S-EPMC9988903","cross_references":{"pubmed":["36896235"],"doi":["10.3389/fgene.2023.1106328"]}}