biostudies-literatureNaderi ENIDCD NIH HHS1106328https://www.ebi.ac.uk/biostudies/studies/S-EPMC9988903biostudies-literatureUnknown14Age-related (AR) hearing loss (HL) is the most common sensory impairment with heritability of 55%. The aim of this study was to identify genetic variants on chromosome X associated with ARHL through the analysis of data obtained from the UK Biobank. We performed association analysis between self-reported measures of HL and genotyped and imputed variants on chromosome X from ∼460,000 white Europeans. We identified three loci associated with ARHL with a genome-wide significance level (p < 5 × 10^-8), <i>ZNF185</i> (rs186256023, <i>p</i> = 4.9 × 10^-10) and <i>MAP7D2</i> (rs4370706, <i>p</i> = 2.3 × 10^-8) in combined analysis of males and females, and <i>LOC101928437</i> (rs138497700, <i>p</i> = 8.9 × 10^-9) in the sex-stratified analysis of males. <i>Frontiers in geneticsThe genetic contribution of the X chromosome in age-related hearing loss.PMC9988903R01 DC017712Li GNaderi ESchrauwen IWang GTLeal SMCornejo-Sanchez DMDewan ATfalseThe genetic contribution of the X chromosome in age-related hearing loss.Age-related (AR) hearing loss (HL) is the most common sensory impairment with heritability of 55%. The aim of this study was to identify genetic variants on chromosome X associated with ARHL through the analysis of data obtained from the UK Biobank. We performed association analysis between self-reported measures of HL and genotyped and imputed variants on chromosome X from ∼460,000 white Europeans. We identified three loci associated with ARHL with a genome-wide significance level (p < 5 × 10^-8), <i>ZNF185</i> (rs186256023, <i>p</i> = 4.9 × 10^-10) and <i>MAP7D2</i> (rs4370706, <i>p</i> = 2.3 × 10^-8) in combined analysis of males and females, and <i>LOC101928437</i> (rs138497700, <i>p</i> = 8.9 × 10^-9) in the sex-stratified analysis of males. <i>2023-01-01T00:00:00Z20232026-05-13T14:35:12.808Z2025-02-19T03:26:17.443ZS-EPMC99889033689623510.3389/fgene.2023.1106328