{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Salowe RJ"],"funding":["Regeneron Pharmaceuticals","National Eye Institute, Bethesda, MD","NEI NIH HHS","Research to Prevent Blindness","The Paul and Evanina Bell Mackall Foundation Trust","F. M. Kirby Foundation","UPenn Hospital Board of Women Visitors"],"pagination":["e001120"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9990679"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(1)"],"pubmed_abstract":["Background/aims
To investigate the rates of structural and functional progression of primary open-angle glaucoma in an African ancestry cohort and identify risk factors for progression.Methods
This retrospective study included 1424 eyes from glaucoma cases in the Primary Open-Angle African American Glaucoma Genetics cohort, with ≥2 visits for retinal nerve fibre layer (RNFL) thickness and mean deviation (MD) measurements over ≥6-month follow-up. The rates of structural progression (change in RNFL thickness/year) and functional progression (change in MD/year) were calculated from linear mixed effects models, accounting for intereye correlation and longitudinal correlation. Eyes were categorised as slow, moderate or fast progressors. Risk factors for progression rates were as"],"journal":["BMJ open ophthalmology"],"pubmed_title":["Risk factors for structural and functional progression of primary open-angle glaucoma in an African ancestry cohort."],"pmcid":["PMC9990679"],"funding_grant_id":["P30 EY001583","R01 EY023557","1RO1EY023557-01","L30 EY029353","K08 EY029765"],"pubmed_authors":["Lee R","Di Rosa I","O'Brien JM","Addis V","Salowe RJ","Cui QN","Miller-Ellis E","Sankar PS","Ying GS","Gudiseva HV","Chen Y","Ross AG","Daniel E","Zenebe-Gete S"],"additional_accession":[]},"is_claimable":false,"name":"Risk factors for structural and functional progression of primary open-angle glaucoma in an African ancestry cohort.","description":"Background/aims
To investigate the rates of structural and functional progression of primary open-angle glaucoma in an African ancestry cohort and identify risk factors for progression.Methods
This retrospective study included 1424 eyes from glaucoma cases in the Primary Open-Angle African American Glaucoma Genetics cohort, with ≥2 visits for retinal nerve fibre layer (RNFL) thickness and mean deviation (MD) measurements over ≥6-month follow-up. The rates of structural progression (change in RNFL thickness/year) and functional progression (change in MD/year) were calculated from linear mixed effects models, accounting for intereye correlation and longitudinal correlation. Eyes were categorised as slow, moderate or fast progressors. Risk factors for progression rates were as","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Mar","modification":"2026-06-14T06:26:43.372Z","creation":"2026-06-14T03:15:46.81Z"},"accession":"S-EPMC9990679","cross_references":{"pubmed":["37278425"],"doi":["10.1136/bmjophth-2022-001120"]}}