biostudies-literatureSalowe RJRegeneron PharmaceuticalsNational Eye Institute, Bethesda, MDNEI NIH HHSResearch to Prevent BlindnessThe Paul and Evanina Bell Mackall Foundation TrustF. M. Kirby FoundationUPenn Hospital Board of Women Visitorse001120https://www.ebi.ac.uk/biostudies/studies/S-EPMC9990679biostudies-literatureUnknown8(1)<h4>Background/aims</h4>To investigate the rates of structural and functional progression of primary open-angle glaucoma in an African ancestry cohort and identify risk factors for progression.<h4>Methods</h4>This retrospective study included 1424 eyes from glaucoma cases in the Primary Open-Angle African American Glaucoma Genetics cohort, with ≥2 visits for retinal nerve fibre layer (RNFL) thickness and mean deviation (MD) measurements over ≥6-month follow-up. The rates of structural progression (change in RNFL thickness/year) and functional progression (change in MD/year) were calculated from linear mixed effects models, accounting for intereye correlation and longitudinal correlation. Eyes were categorised as slow, moderate or fast progressors. Risk factors for progression rates were asBMJ open ophthalmologyRisk factors for structural and functional progression of primary open-angle glaucoma in an African ancestry cohort.PMC9990679P30 EY001583R01 EY0235571RO1EY023557-01L30 EY029353K08 EY029765Lee RDi Rosa IO'Brien JMAddis VSalowe RJCui QNMiller-Ellis ESankar PSYing GSGudiseva HVChen YRoss AGDaniel EZenebe-Gete SfalseRisk factors for structural and functional progression of primary open-angle glaucoma in an African ancestry cohort.<h4>Background/aims</h4>To investigate the rates of structural and functional progression of primary open-angle glaucoma in an African ancestry cohort and identify risk factors for progression.<h4>Methods</h4>This retrospective study included 1424 eyes from glaucoma cases in the Primary Open-Angle African American Glaucoma Genetics cohort, with ≥2 visits for retinal nerve fibre layer (RNFL) thickness and mean deviation (MD) measurements over ≥6-month follow-up. The rates of structural progression (change in RNFL thickness/year) and functional progression (change in MD/year) were calculated from linear mixed effects models, accounting for intereye correlation and longitudinal correlation. Eyes were categorised as slow, moderate or fast progressors. Risk factors for progression rates were as2023-01-01T00:00:00Z2023 Mar2026-06-14T06:26:43.372Z2026-06-14T03:15:46.81ZS-EPMC99906793727842510.1136/bmjophth-2022-001120