{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Muti IH"],"funding":["Massachusetts General Hospital","NIA NIH HHS","NCI NIH HHS","National Institutes of Health","NIH HHS"],"pagination":["e4868"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9992016"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["36(4)"],"pubmed_abstract":["High-resolution magic angle spinning (HRMAS) nuclear magnetic resonance (NMR)-based metabolomics has demonstrated its utility in studies of biofluids for various diseases. HRMAS NMR spectroscopy is uniquely well suited for analyzing human blood samples because of the small quantity of samples and minimal preparation required. To develop this methodology into standardized clinical protocols, establishment of the method's quality assurance (QA) and evaluations of its quality control (QC) are critical. This study aims to assess the QA/QC measured from human blood specimens in the form of serum and plasma through within-subject and between-subject comparisons, as well as stability and consistency comparisons over several freezing-thawing cycles of sample storage conditions, and most importantly, the agreement of pooled control samples against individual samples."],"journal":["NMR in biomedicine"],"pubmed_title":["Designing a quality assurance process for quality control of nuclear magnetic resonance metabolomics studies of human blood."],"pmcid":["PMC9992016"],"funding_grant_id":["P30 AG062421","R01 CA273010","R21 CA243255","S10 OD023406","R01 AG070257","R01 CA115746"],"pubmed_authors":["Feldman AS","Arnold SE","Gonzalez Sanchez-Dahl M","Weng J","Hyman BT","Kivisakk P","Mercaldo ND","Cheng LL","Muti IH","Zhong AB","Fuzesi MV"],"additional_accession":[]},"is_claimable":false,"name":"Designing a quality assurance process for quality control of nuclear magnetic resonance metabolomics studies of human blood.","description":"High-resolution magic angle spinning (HRMAS) nuclear magnetic resonance (NMR)-based metabolomics has demonstrated its utility in studies of biofluids for various diseases. HRMAS NMR spectroscopy is uniquely well suited for analyzing human blood samples because of the small quantity of samples and minimal preparation required. To develop this methodology into standardized clinical protocols, establishment of the method's quality assurance (QA) and evaluations of its quality control (QC) are critical. This study aims to assess the QA/QC measured from human blood specimens in the form of serum and plasma through within-subject and between-subject comparisons, as well as stability and consistency comparisons over several freezing-thawing cycles of sample storage conditions, and most importantly, the agreement of pooled control samples against individual samples.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2024-10-15T03:47:14.781Z","creation":"2024-10-15T03:47:14.781Z"},"accession":"S-EPMC9992016","cross_references":{"pubmed":["36330660"],"doi":["10.1002/nbm.4868"]}}